Autoimmune Diseases of the Nervous System; Inflammation; Microglia; Nervous System Autoimmune Disease, Experimental; Neuroimmunology; Neuromyelitis Optica
We are interested in the initiation, progression and resolution of inflammatory lesions of the central nervous system, and study these processes in models of two important human diseases, i.e. neuromyelitis optica and multiple sclerosis.
Techniques, methods & infrastructure
We routinely establish cultures of CNS antigen-specific T cells, microglia, astrocytes, brain endothelial cells, oligodendrocytes and choroid plexus epithelium. Other tools and methods available include experimental models for multiple sclerosis and neuromyelitis optica, immunological test procedures to identify and quantify cytokine production and antigen-reactivity of T lymphocytes, immunohistochemical analysis, gene expression studies using real-time PCR, pathway focused or whole genome microarrays on fresh and archival (paraformaldehyde-fixed, paraffin embedded) material, and the identification of mimotopes binding to pathogenic autoantibodies.