Endocytosis; Muscles; Neuromuscular Junction; Phosphoprotein Phosphatases; Protein Trafficking; Proteomics; Receptor Tyrosine Kinases; Signal Transduction
My work is focused on characterizing how receptor tyrosine kinases induce intracellular signaling cascades thereby regulating crucial cellular processes including cell proliferation, differentiation and function. My long-term interests center around the receptor tyrosine kinase MuSK. As postdoctoral fellow and subsequently as independent group leader, together with my laboratory, I made important contributions to the function of MuSK and to the characterization of downstream signaling events. More recently I have also become interested in protein trafficking and the interplay between signaling and protein endocytosis. In this respect, we have identified a novel guanidine nucleotide exchange factor with potential function in T cell responses during inflammatory conditions.
For more information visit https://immunologie.meduniwien.ac.at/science-research/research-groups/ruth-herbst/?L=1
Techniques, methods & infrastructure
Experimental strategies include muscle cell cultures and their manipulation (retroviral-mediated gene transduction), confocal microscopy as well as in vivo imaging and analysis of transgenic animal models. Biochemistry, molecular biology and cell biology techniques complete our approaches.