Professor of Pathophysiology and Allergy Research
Division of Immunopathology
Department of Pathophysiology and Allergy Research
Center for Pathophysiology, Infectiology and Immunology
Währinger Gürtel 18-20, 1090 Vienna, Austria
Phone: +43 (0)1 40400 - 51150
FAX: +43 (0)1 40400 - 51300
Molecular, immunological and structural characterization of allergen-specific antibodies to answer fundamental questions regarding the interaction allergen/IgE antibodies as well as to develop tools for diagnosis, prevention and treatment of allergy.
The regulatory role of allergen-specific IgE and IgG antibodies within type I allergy
Our research interest is to understand the contribution of allergen-specific IgE and IgG antibodies in grass and tree pollen allergy.
We therefore focus on the generation of human ScFv libraries and isolation of allergen-specific ScFvs.
We characterize our allergen-specific ScFvs with regard to affinity, cross-reactivity and inhibition potential to block the IgE recognition of major grass and tree pollen allergens.
Those ScFvs that possess blocking potential and high affinity to their corresponding allergens are converted into complete IgG antibodies and their ability for passive treatment and prevention will be determined in vitro and in vivo.
A second focus is the analysis of the human IgE VH repertoire and resulting IgE antibodies for defined allergens.
These investigations allow on the one side to answer questions regarding the rules of pairing of heavy and light chains for obtaining allergen-specificity and on the other side to study its impact on effector cell activation and allergenic activity.
E. Gadermaier, S. Flicker, K. Blatt, P. Valent, R. Valenta (2013). Possible therapeutic potential of a recombinant group 2 grass pollen allergen-specific antibody fragment. Allergy, accepted.
S. Flicker, B. Linhart, C. Wild, U. Wiedermann, R. Valenta (2013). Passive immunization with allergen-specific IgG antibodies for treatment and prevention of allergy, Immunobiology 218:884-891.