Professor of Surgery
Department of Surgery
Medical University of Vienna
Währinger Gürtel 18-20, 1090 Vienna, Austria
Phone: +43 (0)1 40400 - 69760
Fax: +43 (0)1 40400 - 68720
Instruction of transplantation. Costimulation blockade. Immunosuppression. Tolerance through chimerism.
Molecular mechanisms of immune cell development and function
Our main focus is induction of transplantation tolerance through mixed chimerism (i.e. coexistence of donor and recipient hematopoietic cells in the host, established through the transplantation of donor hematopoietic stem cells).
This strategy leads to a particularly robust state of immunological tolerance and has been demonstrated to work not only in rodents, but also in large animals and notably in pilot series of renal transplant patients.
We are also interested in exploring tolerance induction through molecular chimerism for other immunological disorders, such as IgE-mediated allergy.
Costimulation blockade is a critical part of the experimental tolerance protocols we explore. Moreover, it has recently reached the clinical setting as new class of immunosuppressants whose mechanisms we are investigating in a bedside-to-bench approach.
More information about the various research projects can be found at: