The Superti-Furga laboratory addresses the mechanisms by which cells respond to challenges that perturb homeostasis, may these challenges be drugs, viruses or oncogenic mutations, and how homeostasis can subsequently be restored. Strategically, the laboratory investigates large networks of proteins, genes and metabolites, while also focusing on the mechanistic understanding of individual proteins, protein complexes and drug function. How does a drug really work, what are its cellular binding partners or targets, what molecular effects does it cause? How does a virus perturb a cell without the cell noticing? And which are the cell’s weapons to thwart such an attack? Can one detect a perturbed and thus vulnerable “state” of cancer cells, particularly leukemia, by looking at the composition and regulation of the molecular machinery?
The research focus in the Superti-Furga laboratory is on challenging existing paradigms of drug, virus or oncogene action to obtain novel, more comprehensive views that take biological complexity into consideration in view of links to many genes and gene products, investigating metabolism and drug synergies. Efforts are focused on blood cancers, metabolism, infection and inflammation. The approach is truly interdisciplinary and involves functional genomics and proteomics, structural analysis, chemical biology, high-content imaging, bioinformatics and physiology, reflecting the blend of expertise of the laboratory members.
Rebsamen M, et al. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature. 2015 Mar 26;519(7544):477-81. (abstract)
Huber KV, et al. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature. 2014 Apr 10;508(7495):222-7. (abstract)
Pichlmair A, et al. Viral immune modulators perturb the human molecular network by common and unique strategies. Nature. 2012 Jul 26;487(7408):486-90. (abstract)
Gavin AC, et al. Proteome survey reveals modularity of the yeast cell machinery. Nature. 2006 Mar 30;440(7084):631-6. (abstract)
Gavin AC, et al. Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7. (abstract)