Fibroblast biology, cell-to-cell adhesion, tissue formation and remodeling, cytoskeleton, cell migration.

techniques and infrastructure of the research group:

3D-cell culture, immunohistochemistry,  biochemistry (immunoblotting, immunoprecipitation), rtPCR, immunofluorescence – confocal microscopy, life cell imaging – dual photon microscopy, siRNA knock down, cell migration assays, cell invasion assays

Kiener HP, Karonitsch T. The synovium as a privileged site in rheumatoid arthritis: cadherin-11 as a dominant player in synovial pathology. Best Pract Res Clin Rheumatol. 2011 Dec;25(6):767-77.

Kiener HP, Watts GFM, Cui Y, Wright J, Thornhill TS, Skold M, Behar SM, Niederreiter B, Lu J, Cernadas MM, Smolen JS, Warman ML, Brenner MB, Lee DM. Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture. Arthritis Rheum. 2010 Mar;62(3):742-52.

Kiener HP, Niederreiter B, Lee DM, Jimenez-Boj E, Smolen JS, Brenner MB.
Cadherin-11 promotes invasive behavior of fibroblast-like synoviocytes. Arthritis Rheum. 2009 May;60(5):1305-10.

Lee DM, Kiener HP, Agarwal SK, Noss EH, Watts GF, Chisaka O, Takeichi M,
Brenner MB. Cadherin-11 in synovial lining formation and pathology in arthritis. Science. 2007 Feb 16;315(5814):1006-10.

Kiener HP, Stipp CS, Allen PG, Higgins JM, Brenner MB. The cadherin-11 cytoplasmic juxtamembrane domain promotes alpha-catenin turnover at adherens junctions and intercellular motility. Mol Biol Cell. 2006 May;17(5):2366-76.