The work of Dr. Gstoettner was originally focused on improving surgical techniques for cochlear implantation (Gstoettner et al., 1997) and cochlear implant electrode design (Adunka et al., 2004). Advances in these fields allowed for cochlear implantation in partially deaf patients with high rates of hearing preservation (Kiefer et al., 2005). More recently, the research group started to evaluate glucocorticoids for protective effects in models for inner ear trauma (Ye et al., 2007). Currently the group is working on the improvement of drug delivery to the inner ear and the evaluation of novel compounds for otoprotective effects. Therefore, models for cochlear implantation and hearing loss have been established. Methods used include electrophysiological measurements for the determination of hearing thresholds in rodents and perilymph-sampling techniques, which facilitate the quantification of intracochlear drug levels.
Additionally, the large pool of patients with hearing loss and cochlear implants at the department for otorhinolaryngology enables the group to conduct clinical studies.
A new electrode for residual hearing preservation in cochlear implantation: first clinical results.
Gstoettner W, Helbig S, Settevendemie C, Baumann U, Wagenblast J, Arnoldner C.
Acta Otolaryngol. 2009 Apr;129(4):372-9.
Electric acoustic stimulation of the auditory system: results of a multi-centre investigation.
Gstoettner WK, van de Heyning P, O'Connor AF, Morera C, Sainz M, Vermeire K, Mcdonald S, Cavallé L, Helbig S, Valdecasas JG, Anderson I, Adunka OF.
Acta Otolaryngol. 2008 Sep;128(9):968-75.
Application of a corticosteroid (Triamcinolon) protects inner ear function after surgical intervention.
Ye Q, Tillein J, Hartmann R, Gstoettner W, Kiefer J
Ear Hear. 2007 Jun;28(3):361-9.
Ipsilateral electric acoustic stimulation of the auditory system: results of long-term hearing preservation.
Gstoettner WK, Helbig S, Maier N, Kiefer J, Radeloff A, Adunka OF.
Audiol Neurootol. 2006;11 Suppl 1:49-56.
Combined electric and acoustic stimulation of the auditory system: results of a clinical study.
Kiefer J, Pok M, Adunka O, Stürzebecher E, Baumgartner W, Schmidt M, Tillein J, Ye Q, Gstoettner W.
Audiol Neurootol. 2005 May-Jun;10(3):134-44.