Anton Borger

Department(s): Division of Plastic and Reconstructive Surgery (Department of Surgery)
Position: PHD Student
Location: Währingergürtel 18-20
E-Mail:

Abstract:

I am investigating ways to improve regeneration after peripheral nerve injuries (PNI). Recent studies showed that adipose tissue-derived stem cells (ADSC) and subsequently extracellular vesicles (EV) released by ADSCs can promote nerve regeneration in experimental model. The aim of my PhD project is to compare ADSCs and ADSC-derived EVs based on their capabilities to enhance nerve regeneration in rats. Shedding further light on ADSCs and especially on EVs will bring us one step closer to release the promising potential in clinical use one day.

Techniques:

The techniques performed in this project can be divided into two main categories,

a) working with ADSCs and EVs in primary cell culture:

• Primary cell culture
• Differential centrifugation
• Electron microscopy
• Nanotracking analysis and

b) methods to obtain functional and histomorphological parameter after PNI:

• Walking track analysis
• Immunofluorescence.

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