Ksenija Martinovic, MSc

Department(s): Department of Pathobiology of the Nervous System (Center for Brain Research)
Position: PHD Student
Location: Spitalgasse 4
Telephone: 40160 - 34091
E-Mail:

Principle Investigator(s):

• Berger, Johannes

Abstract:

 X-linked adrenoleukodystrophy  is a neurometabolic disorder caused by mutations in the ABCD1 gene encoding the peroxisomal half-transporter ABCD1. In its severest form, X-ALD characterized by progressive, inflammatory demyelination in the brain. The contribution of myelin-producing oligodendrocytes to the pathophysiology of X-ALD still remains largely unknown. We are conducting neuropathological analyses on human post mortem X-ALD tissue to gain insight into the status of oligodendrocytes within the demyelinative lesions. Furthermore, by utilizing the cuprizone-induced demyelination paradigm in Abcd1-deficient mice, we are able to parse out the processes of demyelination and remyelination in the context of the inherent oligodendrocytic metabolic disturbances.   

Techniques:

·  Transcardial perfusion

·  Histology and immunohistochemistry

·  Biochemical analyses (qPCR, Western Blot)

·  RNA in situ hybridization

·  Electron microscopy

Selected Publications:

1. Zierfuss B, Weinhofer I, Kühl J, Köhler W, Bley A, Zauner K, Binder J, Martinović K, Seiser C, Hertzberg C, Kemp S, Egger G, Leitner G, Bauer J, Wiesinger C, Kunze M, Forss-Petter S, Berger J (2020) Vorinostat in the acute neuroinflammatory form of X-linked adrenoleukodystrophy Ann Clin Transl Neurol, 7 (5): 639-652

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