Ao.Univ.Prof. Dr. Jan Bauer

Department(s): Department of Neuroimmunology (Center for Brain Research)
Position: Associate Professor
Location: Spitalgasse 4
Telephone: 40160-34213
E-Mail:

Research Area:
Autoimmune Diseases of the Nervous System

Research Interests:
Antibody-Dependent Cell Cytotoxicity, Autoimmune Diseases of the Nervous System, Cytotoxicity, Immunologic, Encephalitis Viruses, Epilepsy, Multiple Sclerosis

Principle Investigator(s):

• Bauer, Jan (Head)
• Bauer, Jan

Interest Group(s):

• Epilepsy
• Neuroinflammation / Inflammatory Diseases of the Nervous System / Multiple Sclerosis

Grant(s):

• Inflammation and Viruses in Epilepsy (Responsible)
• Treatment of MOG peptide-induced EAE in marmosets (Responsible)

Abstract:

My research focuses on mechanisms of inflammatory diseases of the CNS. In this large area my special interests are the inflammatory reactions in epileptic disorders. The study of Rasmussen encephalitis, antibody-associated encephalitides and other forms of epilepsy are performed in close cooperation with Prof. Dr. Christian Bien in Bielefeld, Germany. This work is complemented by the study of other diseases such as Multiple Sclerosis and various viral encephalitides. Besides the analysis of human brain we also study animal models of autoimmune or virus induced inflammatory CNS disease which may give new insights in the development of CNS inflammation.

Selected Publications:

1. Klang Andrea, Schmidt Peter, Kneissl Sibylle, Bagó Zoltán, Vincent Angela, Lang Bethan, Moloney Teresa, Bien Christian G., Halász Péter, Bauer Jan*, Pákozdy Ákos* (2014) IgG and Complement Deposition and Neuronal Loss in Cats and Humans With Epilepsy and Voltage-Gated Potassium Channel Complex Antibodies J Neuropath Exp Neurol, 73 (5): 403-413. *JB and AP share senior authorship
2. Bauer J, Vezzani A, Bien CG (2012) Epileptic encephalitis: the role of the innate and adaptive immune system Brain Pathol, 22(3): 412-421
   | Article (PDF) |
3. Bien CG, Vincent A, Barnett MH, Becker AJ, Blümcke I, Graus F, Jellinger KA, Reuss DE, Ribalta T, Schlegel J, Sutton I, Lassmann H, Bauer J. (2012) Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis Brain, 135(Pt 5): 1622-1638
   | Article (PDF) |
4. Saxena A*, Bauer J*, Scheikl T, Zapulla J, Audebert M, Desbois S, Waisman A, Lassmann H, Liblau RS, Mars LT (2008) Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes J Immunol, 181(3): 1617-1621. *AS and JB share first authorship
5. Bauer J, Elger CE, Hans VH, Schramm J, Urbach H, Lassmann H, Bien CG (2007) Astrocytes are a specific immunological target in Rasmussen's encephalitis Ann Neurol, 62(1): 67-80

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