- Igor Adameyko
- Oskar Aszmann
- Jan Bauer
- Johannes Berger
- Roland Beisteiner
- Stefan Böhm
- Roland Blumer
- Monika Bradl
- Hakan Cetin
- Ruth Drdla-Schutting
- Margot Ernst
- Michael Freissmuth
- Tibor Harkany
- Wulf Haubensak
- Ruth Herbst
- Romana Höftberger
- Vered Kellner
- Thomas Klausberger
- Helmut Kubista
- Rupert Lanzenberger
- Balint Lasztoczi
- Winfried Neuhaus
- Daniela Pollak
- Andreas Pollreisz
- Christine Radtke
- Harald Sitte
- Wolfgang M. Schmidt
- Petra Scholze
- Elisabeth Stögmann
- Isabelle Weinhofer-Molisch
- Isabella Wimmer
- Lilli Winter
- Fritz Zimprich
- Alumni
Assoc. Prof. Ruth Drdla-Schutting, PhD
Department(s): Division of Neurophysiology (Center for Brain Research)
Position: Assistant Professor
Location: Spitalgasse 4
Telephone: 40160-34126
E-Mail:
Research Area:
Acute Pain, Chronic Pain
Research Interests:
Analgesics, Opioid, Astrocytes, Long-Term Potentiation, Microglia, Neuronal Plasticity, Pharmacogenetics, Spinal Cord
Principle Investigator(s):
Interest Group(s):
Grant(s):
- The role of spinal astrocytes in nociception and pain (Responsible)
- Synaptic long-term potentiation after opioid withdrawal
- The role of spinal astrocytes in nociception and pain
Abstract:
One mechanisms thought to underly the transition of acute to chronic pain is synaptic long-term potentiation at synapses in the superficial spinal cord dorsal horn, which can be induced by strong noxious stimuli such as inflammation or trauma, or upon withdrawal of opioids. I am investigating the mechanisms of induction, maintenance and reversal of this form of synaptic plasticity in the nociceptive system.
My current work is focused on the role of glial cells and the effects of neuron-glial interactions on synaptic transmission and plasticity at synapses in the superficial layers of the spinal cord dorsal horn.
Techniques:
- In vivo electropyhsiology
- In vitro electrophysiology (acute slices)
- Calcium Imaging
- Behavioural Tests
- Immunostainings
- Pharmacosynthetics
Selected Publications:
- Kronschläger MT, Drdla-Schutting R, Gassner M, Honsek SD, Teuchmann HL, Sandkühler J (2016) Gliogenic LTP spreads widely in nociceptive pathways Science, 354: 1144-1148
| Article (PDF): 1 2 | - Gerhold K, Drdla-Schutting R, Honsek S, Forsthuber L, Sandkühler J (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude J Neurosci, 35 (26): 9580-9594
| Article (PDF) || Weblink | - Drdla R, Benrath J, Wunderbaldinger G, Sandkühler J (2012) Erasure of a spinal memory trace of pain by a brief, high-dose opioid administration Science, 335: 235-238
| Article (PDF) || Weblink | - Heinl C, Drdla-Schutting R, Xanthos D, Sandkühler J (2011) Distinct mechanisms underlying pronociceptive effects of opioids J Neurosci, 31(46): 16748–16756
| Article (PDF) || Weblink | - Drdla R., Gassner M., Gingl E., Sandkühler J. (2009) Induction of synaptic long-term potentiation after opioid withdrawal Science, 325: 207-210
| Article (PDF) || Supplement |