Abk�rzung zur Hauptnavigation Abk�rzung zu den Newsmeldungen Abk�rzung zu den Topstories  
  MedUni Vienna    Intranet    MedUni Vienna - Shop    University Library    University Hospital Vienna  
 
phd_neuroscience.png
 
 
 
Hauptnavigation
  • Home
  • General Informations
  • Research Laboratories
  • PhD Students
  • Lectures & Courses
 
PhD Neuroscience / Research Laboratories / Ruth Drdla-Schutting
 
Subnavigation
  • Igor Adameyko
  • Oskar Aszmann
  • Jan Bauer
  • Johannes Berger
  • Roland Beisteiner
  • Stefan Böhm
  • Roland Blumer
  • Monika Bradl
  • Hakan Cetin
  • Ruth Drdla-Schutting
  • Margot Ernst
  • Michael Freissmuth
  • Tibor Harkany
  • Wulf Haubensak
  • Ruth Herbst
  • Romana Höftberger
  • Thomas Klausberger
  • Helmut Kubista
  • Rupert Lanzenberger
  • Balint Lasztoczi
  • Winfried Neuhaus
  • Daniela Pollak-Monje Quiroga
  • Andreas Pollreisz
  • Christine Radtke
  • Harald Sitte
  • Wolfgang M. Schmidt
  • Petra Scholze
  • Elisabeth Stögmann
  • Isabelle Weinhofer-Molisch
  • Isabella Wimmer
  • Lilli Winter
  • Fritz Zimprich
  • Alumni


Inhaltsbereich

Assoc. Prof. Ruth Drdla-Schutting, PhD

Department(s): Department of Neurophysiology (Center for Brain Research)
Position: Assistant Professor
Location: Spitalgasse 4
Telephone: 40160-34126
E-Mail:

Research Area:
Acute Pain, Chronic Pain


Research Interests:
Analgesics, Opioid, Astrocytes, Long-Term Potentiation, Microglia, Neuronal Plasticity, Pharmacogenetics, Spinal Cord


Principle Investigator(s):

  • Drdla-Schutting, Ruth (Head)
  • Sandkühler, Jürgen


Interest Group(s):

  • Neuroinflammation / Inflammatory Diseases of the Nervous System / Multiple Sclerosis
  • Pain Interest Group


Grant(s):

  • The role of spinal astrocytes in nociception and pain (Responsible)
  • Synaptic long-term potentiation after opioid withdrawal
  • The role of spinal astrocytes in nociception and pain


Abstract:

One mechanisms thought to underly the transition of acute to chronic pain is synaptic long-term potentiation at synapses in the superficial spinal cord dorsal horn, which can be induced by strong noxious stimuli such as inflammation or trauma, or upon withdrawal of opioids. I am investigating the mechanisms of induction, maintenance and reversal of this form of synaptic plasticity in the nociceptive system.

My current work is focused on the role of glial cells and the effects of neuron-glial interactions on synaptic transmission and plasticity at synapses in the superficial layers of the spinal cord dorsal horn.


Techniques:

  • In vivo electropyhsiology
  • In vitro electrophysiology (acute slices)
  • Calcium Imaging
  • Behavioural Tests
  • Immunostainings
  • Pharmacosynthetics


Selected Publications:

  1. Kronschlger MT, Drdla-Schutting R, Gassner M, Honsek SD, Teuchmann HL, Sandkhler J (2016) Gliogenic LTP spreads widely in nociceptive pathways Science, 354: 1144-1148
    | Article (PDF): 1 2 |
  2. Gerhold K, Drdla-Schutting R, Honsek S, Forsthuber L, Sandkhler J (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude J Neurosci, 35 (26): 9580-9594
    | Article (PDF) || Weblink |
  3. Drdla R, Benrath J, Wunderbaldinger G, Sandkhler J (2012) Erasure of a spinal memory trace of pain by a brief, high-dose opioid administration Science, 335: 235-238
    | Article (PDF) || Weblink |
  4. Heinl C, Drdla-Schutting R, Xanthos D, Sandkhler J (2011) Distinct mechanisms underlying pronociceptive effects of opioids J Neurosci, 31(46): 1674816756
    | Article (PDF) || Weblink |
  5. Drdla R., Gassner M., Gingl E., Sandkhler J. (2009) Induction of synaptic long-term potentiation after opioid withdrawal Science, 325: 207-210
    | Article (PDF) || Supplement |

Show all publications

 
Drucken
 
 
© MedUni Wien  | 
 Publishing information | Terms of use | Accessibility | Contact