- Igor Adameyko
- Oskar Aszmann
- Jan Bauer
- Johannes Berger
- Roland Beisteiner
- Stefan Böhm
- Roland Blumer
- Monika Bradl
- Hakan Cetin
- Ruth Drdla-Schutting
- Margot Ernst
- Michael Freissmuth
- Andreas Gruber
- Andreas Hahn
- Tibor Harkany
- Ruth Herbst
- Romana Höftberger
- Thomas Klausberger
- Helmut Kubista
- Franco Laccone
- Rupert Lanzenberger
- Balint Lasztoczi
- Ewald Moser
- Vanja Nagy
- Winfried Neuhaus
- Daniela Pollak-Monje Quiroga
- Andreas Pollreisz
- Christine Radtke
- Jürgen Sandkühler
- Harald Sitte
- Wolfgang M. Schmidt
- Petra Scholze
- Elisabeth Stögmann
- Isabelle Weinhofer-Molisch
- Isabella Wimmer
- Lilli Winter
- Fritz Zimprich
- Alumni
Univ. Prof. Dr. Tibor Harkany
Department(s): Department of Molecular Neurosciences (Center for Brain Research)
Position: Professor
Location: Spitalgasse 4
Telephone: 40160-34050
E-Mail:
Download Curriculum vitae (CV)
Research Area:
Calcium, Diabetes Mellitus, Type 2, Endocannabinoids
Research Interests:
Child Development, Developmental Biology, Endocannabinoids, Synapses
Principle Investigator(s):
Interest Group(s):
Grant(s):
- FOODFORLIFE: Life-long cross-generational priming of the hypothalamus for obesity (Responsible)
- SECRET-CELLS (Responsible)
Molecular Neurobiology
Abstract:
The nervous system consists of a kaleidoscope of molecularly distinct neurons and glial cells whose local, as well as long-distance communication underpin specific behaviors. We are interested in elucidating key developmental mechanisms that control the molecular diversification of neurons, and their activity-dependent integration in emergent neuronal networks. We are particularly interested in the study of how bioactive lipid signals orchestrate histogenesis via cell type-sepcific receptor systems. Moreover, we are studying the role of neuron-specific calcium-binding (sensor) proteins in neurons and neuroendocrine cells. Our work is expected to increase knowledge on the molecular pathobiology of prenatal cannabis exposure, epilepsy and diabetes.
Techniques:
Our repertoire of techniques include molecular biology, mouse genetics, neuroanatomy, protein biochemistry, electrophysiology and advanced imaging. Our laboratory has taken delivery of a number of state-of-the-art technical paltforms as first in Austria, including automated, laser-assisted Western blotting systems (GE) and a light-sheet microscope (Zeiss). We also employ tissue clearing protocols to appropriately resolve the morphological heterogeneity of neurons.
Selected Publications:
- Tortoriello G, Morris CV, Alpar A, Fuzik J, Shirran SL, Calvigioni D, Keimpema E, Botting CH, Reinecke K, Herdegen T, Courtney M, Hurd YL, Harkany T (2014) Miswiring the brain: delta9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway Embo Journ, : published online 27.01.2014
- Zhang M, Tortoriello G, Hsueh B, Tomer R, Ye L, Mitsios N, Borgius L, Grant G, Kiehn O, Watanabe M, Uhlen M, Mulder J, Deisseroth K, Harkany T, Hökfelt T (2014) Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury PNAS, 111 (12): E1149-E1158
- Malenczyk K, Jazurek M, Keimpema E, Silvestri C, Janikiewicz J, Mackie K, Di Marzo V, Redowicz MJ, Harkany T, Dobrzyn A (2013) CB1 Cannabinoid Receptors Couple to Focal Adhesion Kinase to Control Insulin Release J Biol Chem, 288: 32685-32699
- Keimpema E, Tortoriello G, Alpar A, Capsoni S, Arisi I, Calvigioni D, Hu S, Cattaneo A, Doherty P, Mackie K, Harkany T (2013) Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons PNAS, 110: 1935-1940