Assoc.-Prof. Priv.-Doz. Mag. Barbara Messner, PhD

Head of the Cardiac Surgery Research Laboratory

Department of Surgery

Medical University of Vienna

AKH, Level 8, Room G9.03

Vienna A-1090

Phone: 01-40400-69490

E-Mail: barbara.messner@meduniwien.ac.at

Homepage: https://www.meduniwien.ac.at/hp/herzchirurgie/wissenschaft-forschung/forschungslabor-herzchirurgie-research-group-barbara-messner/

Know how and research interest:

Our main research focus is to understand – and based on this understanding to prevent and treat different Cardiovascular Diseases as for example the development of ascending aortic aneurysms. The approach chosen is a multi-disciplinary and application-oriented research strategy. The team seeks to establish and strengthen a network to achieve its research goals. Cooperation with analytical and synthetic chemistry groups, pharmacological groups, bio-medical research laboratories, and in vivo analyses are central to most projects. The know-how and methods of the team range from molecular biology, via cell biology, animal experimentation and histological analyses to human studies.

Research topics:

Development and pathophysiology of Cardiovascular Diseases (e.g. myocardial infarction, thoracic aortic aneurysms, bypass restenosis)

Techniques

·        Isolation and culture of different primary cells from various vascular tissues

·        Western Blotting

·        Flow cytometry

·        Immunohistochemistry/Immunofluorescence stainings on different tissues

·        Confocal-based microscopy of cell and tissues

·        Electron microscopy

·        Cell based functional assays

5 selected publications

1.      Christian Stern, Bernhard Scharinger, Adrian Tuerkcan, Clemens Nebert, Teresa Mimler, Ulrike Baranyi, Christian Doppler, Thomas Aschacher, Martin Andreas, Marie-Elisabeth Stelzmueller, Marek Ehrlich, Alexandra Graf, Guenther Laufer, David Bernhard and Barbara Messner. Strong Signs for a Weak Wall in Tricuspid Aortic Valve Associated Aneurysms and a Role for Osteopontin in Bicuspid Aortic Valve Associated Aneurysms. Int. J. Mol. Sci. 2019, 20(19), 4782; doi.org/10.3390/ijms20194782

2.      Teresa Mimler, Clemens Nebert, Eva Eichmair, Birgitta Winter, Thomas Aschacher, Marie-Extracellular matrix in ascending aortic aneurysms and dissections - What we learn from decellularization and scanning electron microscopyElisabeth Stelzmueller, Martin Andreas, Marek Ehrlich, Guenther Laufer, Barbara Messner. PLoS One. 2019 Mar 18;14(3):e0213794. doi: 10.1371/journal.pone.0213794. eCollection 2019.

3.      Franziska Wittmann, Adrian Türkcan, Ulrike Baranyi, Eva Eichmair, Günther Laufer, David Bernhard, Barbara Messner. To Be Or Not to Be: the "Smoker's Paradox" - An in-Vitro Study. Cell Physiol Biochem. 2018;48(4):1638-1651. doi: 10.1159/000492285. Epub 2018 Aug 3.

4.      Barbara Messner, Adrian Türkcan, Christian Ploner, Günther Laufer, David Bernhard. Cadmium overkill: autophagy, apoptosis and necrosis signalling in endothelial cells exposed to cadmium. Cell Mol Life Sci. 2016 Apr;73(8):1699-713. doi: 10.1007/s00018-015-2094-9. Epub 2015 Nov 20.

5.      Adrian Türkcan, Bernhard Scharinger, Gerlinde Grabmann, Bernhard K Keppler, Günther Laufer, David Bernhard, Barbara Messner. Combination of cadmium and high cholesterol levels as a risk factor for heart fibrosis. Toxicol Sci. 2015 Jun;145(2):360-71. doi: 10.1093/toxsci/kfv057. Epub 2015 Mar 13.

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