Univ. Prof. Dr. Bruno Podesser
Department of Biomedical Research, Medical University of Vienna
know-how and research interests:
My group is focusing on ischemia/reperfusion (I/R) injury and post-myocardial infarction (MI) remodeling. I/R is critical in clinical situations such as acute coronary syndrome and myocardial infarction. If not addressed properly by re-opening of the vessel, it leads to post-MI remodeling and ultimately to heart failure. Our concept of myocardial protection during I/R starts with endothelial protection by administration of NO donors during acute and chronic ischemia. In post MI remodeling we study the aspect of inflammation on extracellular matrix proteins.
ischemia/reperfusion and postMI remodeling in the heart
Techniques and infrastructure of the research group
animal models for ischemia/reperfusion from the mouse to the pig; isolated heart preparation in mouse, rat and rabbit; acute and chronic hemodynamic monitoring, high-energy phosphate analysis; one full-time technician.
5 selected publications:
Acceptance of animal research in our science community.
Bergmeister K, Podesser B.
Version 2. F1000Res. 2016 Mar 4 [revised 2016 Jul 8];5:282. doi: 10.12688/f1000research.8169.2. eCollection 2016.
Short-term clinical outcomes between intermittent cold versus intermittent warm blood cardioplegia in 2200 adult cardiac surgery patients.
Trescher K, Gleiss A, Boxleitner M, Dietl W, Kassal H, Holzinger C, Podesser BK.
J Cardiovasc Surg (Torino). 2015 Feb 12. [Epub ahead of print]
Myofilament protein carbonylation contributes to the contractile dysfunction in the infarcted LV region of mouse hearts.
Balogh A, Santer D, Pásztor ET, Tóth A, Czuriga D, Podesser BK, Trescher K, Jaquet K, Erdodi F, Edes I, Papp Z.
Cardiovasc Res. 2014 Jan 1;101(1):108-19. doi: 10.1093/cvr/cvt236. Epub 2013 Oct 14.
The continuing evolution of the Langendorff and ejecting murine heart: new advances in cardiac phenotyping.
Liao R, Podesser BK, Lim CC.
Am J Physiol Heart Circ Physiol. 2012 Jul 15;303(2):H156-67. doi: 10.1152/ajpheart.00333.2012. Epub 2012 May 25. Review.
Nitric oxide homeostasis as a target for drug additives to cardioplegia.
Podesser BK, Hallström S.
Br J Pharmacol. 2007 Aug;151(7):930-40. Epub 2007 May 8. Review.