Department of Internal Medicine II, Division of Cardiology
Medical University of Vienna, AKH
Waehringer Guertel 18-20, 1090 Vienna, Austria
Close to half of patients presenting with symptoms of heart failure are found to have a near normal left ventricular ejection fraction. This condition has been labeled ‘diastolic heart failure’ or ‘heart failure with preserved ejection fraction’ (HFPEF). Patients with HFPEF face adverse outcomes with respect to morbidity and mortality, and their prognosis is similar to that of patients with systolic heart failure.
The pathophysiology underlying HFPEF is still incompletely understood. My group’s research focuses around epidemiology, pathophysiology, diagnosis and therapy of this disease. This is accomplished by clinical studies in the setting of a newly founded tertiary referral center for HFPEF as well translational studies including novel imaging techniques.
Pulmonary hypertension in left heart disease, heart failure with preserved ejection fraction
Referral center for patients with HFPEF, cardiac MRI (in collaboration with J. Mascherbauer), myocardial biopsy, immunohistochemistry, ELISA, animal models
5 selected publications:
1. Ghio S, Bonderman D, Felix SB, Ghofrani HA, Michelakis ED, Mitrovic V, Oudiz RJ, Frey R, Roessig L, Semigran MJ. Left ventricular systolic dysfunction associated with pulmonary hypertension riociguat trial (lepht): Rationale and design. Eur J Heart Fail. 2012.
2. Rosenkranz S, Bonderman D, Buerke M, Felgendreher R, ten Freyhaus H, Grunig E, de Haan F, Hammerstingl C, Harreuter A, Hohenforst-Schmidt W, Kindermann I, Kindermann M, Kleber FX, Kuckeland M, Kuebler WM, Mertens D, Mitrovic V, Opitz C, Schmeisser A, Schulz U, Speich R, Zeh W, Weil J. Pulmonary hypertension due to left heart disease: Updated recommendations of the cologne consensus conference 2011. Int J Cardiol. 2011;154 Suppl 1:S34-44.
3. Martischnig AM, Tichy A, Nikfardjam M, Heinz G, Lang IM, Bonderman D. Inhaled iloprost for patients with precapillary pulmonary hypertension and right-side heart failure. J Card Fail. 2011;17:813-818.
4 Mascherbauer J, Fuchs C, Pernicka E, Wollenek G, Rosenhek R, Bonderman D, Maurer G, Baumgartner H. Predictors of outcome of non-ischemic mitral valve surgery. Int J Cardiol. 2011.
5. Bonderman D, Skoro-Sajer N, Jakowitsch J, Adlbrecht C, Dunkler D, Taghavi S, Klepetko W, Kneussl M, Lang IM. Predictors of outcome in chronic thromboembolic pulmonary hypertension. Circulation2007 Apr 24;115(16):2153-8.