Georg-Christian FUNK, MD, Assoc.Prof.
Otto Wagner Hospital
1140 Vienna, Austria
Know-how and research interests
My group is interested metabolic and inflammatory consequences of subclinical atherosclerosis in chronic obstructive pulmonary disease (COPD).
Patients with COPD are at increased risk of atherosclerosis and cardiovascular events, however, the mechanisms of this association are unclear. In this project we aim to determine the mechanisms of subclinical atherosclerosis in COPD. Specifically we will study the association of glucose metabolism and endothelial dysfunction in patients with COPD. Moreover, we will investigate endothelial function and systemic inflammation in acute exacerbations of COPD. Finally we will study the association between assymmetric dimethyl-arginine and markers of subclinical atherosclerosis in COPD.
Metabolic and inflammatory consequences of subclinical atherosclerosis in chronic obstructive pulmonary disease (COPD)
5 selected publications
Funk GC, Lang I, Schenk P, Valipour A, Hartl S, Burghuber OC. Left ventricular diastolic dysfunction in patients with COPD in the presence and absence of elevated pulmonary arterial pressure.
Petkov V, Mosgöller W, Ziesche R, Raderer M, Stiebellehner L, Vonbank K, Funk GC, Hamilton G, Novotny C, Burian B, Block LH. Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension. J Clin Invest. 2003;111:1339-46.
Funk GC, Bauer P, Burghuber OC, Fazekas A, Hartl S, Hochrieser H, Schmutz R, Metnitz P. Prevalence and Prognosis of Chronic Obstructive Pulmonary Disease in Critically Ill Patients between 1998 and 2008. Eur Respir J. 2012 Sep 27. [Epub ahead of print]
Funk GC, Breyer MK, Burghuber OC, Kink E, Kirchheiner K, Kohansal R, Schmidt I, Hartl S. Long-term non-invasive ventilation in COPD after acute-on-chronic respiratory failure. Respir Med. 2011;105:427-34.
Funk GC, Kirchheiner K, Burghuber OC, Hartl S. BODE index versus GOLD classification for explaining anxious and depressive symptoms in patients with COPD - a cross-sectional study. Respir Res. 2009;10:1.