- Hendrik J. Ankersmit, MD
- Alice Assinger, PhD
- Christoph J. Binder, MD, PhD
- Julia Binder, MD, PhD
- Diana Bonderman, MD
- Johannes Breuss, PhD
- Christine Brostjan, PhD
- Svitlana Demyanets, MD, PhD
- Michael J.M. Fischer MD
- Georg-Christian Funk, MD
- Martin Funovics, MD
- Garhöfer Gerhard
- Georg Goliasch, MD
- Wolfgang Holnthoner, PhD
- Kurt Huber, MD
- Martin Hülsmann
- Bernd Jilma, MD
- Attila Kiss, PhD
- Irene Lang, MD
- Robert Loewe, MD
- Julia Mascherbauer, MD
- Barbara Messner, PhD
- Alexander Niessner, MD, MSc
- Selma Osmanagic-Myers, Dr.in rer. nat.
- Peter Petzelbauer, MD
- Bruno K. Podesser, MD
- Thomas Reiberger, MD
- Gernot Schabbauer, PhD
- Leopold Schmetterer, PhD
- Johannes A. Schmid, PhD
- Klaudia Schossleitner, PhD
- Waltraud Schrottmaier, PhD
- Walter Speidl, MD
- Herbert Stangl, PhD
- Dimitrios Tsiantoulas, PhD
- Ivo Volf, PhD
- Benedikt Weber, Ap. Prof. Priv.-Doz. Dr. Dr.
- Viktoria Weber, PhD
- Wolfgang J. Weninger, MD
- Johann Wojta, PhD
- Maria Zellner, PhD
a.o. Univ. Prof. DI. Dr. Herbert Stangl
work address:
Medical University of Vienna
Center for Pathobiochemistry and Genetics
Department of Medical Chemistry
Währingerstr. 10, 1090 Vienna, Austria
e-mail:
Herbert.stangl@meduniwien.ac.at
homepage:
know-how and research interests:
→Lipoprotein metabolism: Transfer of cholesterol between lipoproteins and cells, in particular reverse cholesterol transport by HDL. Cellular HDL particle uptake and resecretion, the signaling behavior of HDL and their physiological relevance
research topic:
HDL Lipid Transfer
techniques and infrastructure of the research group:
Diverse basic molecular and cellular biology techniques, immunological and functional assays, subcellular fractionation, immunohistochemistry, confocal microscopy, electron microscopy, lipoprotein isolation, profiling and labeling, gas- and thinlayer-chromotography for lipid analysis
5 selected publications:
Lipoprotein Particles Interact with Membranes and Transfer Their Cargo without Receptors. Plochberger B, Sych T, Weber F, Novacek J, Axmann M, Stangl H, Sezgin E. Biochemistry. 2020 Nov 4. doi: 10.1021/acs.biochem.0c00748. Online ahead of print.
Receptor-Independent Transfer of Low Density Lipoprotein Cargo to Biomembranes. Axmann M, Sezgin E, Karner A, Novacek J, Brodesser MD, Röhrl C, Preiner J, Stangl H, Plochberger B. Nano Lett. 2019 Apr 10;19(4):2562-2567. doi: 10.1021/acs.nanolett.9b00319. Epub 2019 Mar 8
HDL particles incorporate into lipid bilayers - a combined AFM and single molecule fluorescence microscopy study. Plochberger B, Röhrl C, Preiner J, Rankl C, Brameshuber M, Madl J, Bittman R, Ros R, Sezgin E, Eggeling C, Hinterdorfer P, Stangl H, Schütz GJ. Sci Rep. 2017 Nov 21;7(1):15886. doi: 10.1038/s41598-017-15949-7.
Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells. Röhrl C, Eigner K, Winter K, Korbelius M, Obrowsky S, Kratky D, Kovacs WJ, Stangl H. J Lipid Res. 2014 Jan;55(1):94-103.
SR-BI-mediated high density lipoprotein (HDL) endocytosis leads to HDL resecretion facilitating cholesterol efflux.Pagler TA, Rhode S, Neuhofer A, Laggner H, Strobl W, Hinterndorfer C, Volf I, Pavelka M, Eckhardt ER, van der Westhuyzen DR, Schütz GJ, Stangl H. J Biol Chem. 281:11193-111204 (2006).