Univ. Prof. Dr. Peter Petzelbauer

work address:

Medical University of Vienna
Skin & Endothelial research division SERD
Department of Dermatology
Lazarettgasse 14a, 1090 Vienna, Austria

Phone: +43 (0)1 40400 73786

E-Mail: peter.petzelbauer@meduniwien.ac.at

Homepage: www.serd.at,
http://www.meduniwien.ac.at/dermatologie/vascbiol/petzelbauer.html

Know-how and research interests

The Skin & Endothelium Research Division SERD is a basic biomedical research laboratory. With our work at the cutting edge of dermatology we strive to contribute to a better understanding of skin-specific endothelial responses in inflammation and cancer. This understanding will lead directly to applied research projects with our partners and will ultimately have an impact on new therapies for endothelial responses to inflammation and tumor growth.

Research topics

Protection of vascular barrier function in acute lung injury
Mechanisms of lymphogenic tumor spread

Techniques and infrastructure of the research group

Qualitative and quantitative methods in protein biochemistry and molecular biology, cell and tissue culture, transfection of cells, expression and purification of recombinant proteins, sub cellular fractionation and analysis of subcellular fractions, flow cytometry, histology and immuno-histochemistry, metastatic melanoma mouse models, metastatic tumor models in chicken eggs, models for acute lung injury.

5 selected publications

Wenzina J, Holzner S, Puujalka E, Cheng PF, Forsthuber A, Neumüller K, Schossleitner K, Lichtenberger BM, Levesque MP, Petzelbauer P. Inhibition of p38/MK2 signaling prevents vascular invasion of melanoma. J Invest Dermatol. 2020;140:878-890.e5 doi.org/10.1016/j.jid.2019.08.451

Niederleithner H, Heinz M, Tauber S, Bilban M, Pehamberger H, Sonderegger S, Knöfler M, Bracher A, Berger W, Loewe R, Petzelbauer P. Wnt1 is anti-lymphangiogenic in a melanoma mouse model. J Invest Dermatol 2012 132(9):2235-44

Loewe R, Valero T, Kremling S, Pratscher B, Kunstfeld R, Pehamberger H, Petzelbauer P. Dimethylfumarate impairs melanoma growth and metastasis. Cancer Res. 2006 Dec 15;66(24):11888-96

Gröger M, Pasteiner W, Ignatyev G, Matt U, Knapp S, Atrasheuskaya A, Bukin E, Friedl P, Zinkl D, Hofer-Warbinek R, Zacharowski K, Petzelbauer P, Reingruber S. Peptide Bbeta(15-42) preserves endothelial barrier function in shock. PLoS One. 2009;4(4):e5391

Petzelbauer P, Zacharowski PA, Miyazaki Y, Friedl P, Wickenhauser G, Castellino FJ, Gröger M, Wolff K, Zacharowski K. The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nat Med. 2005 Mar;11(3):298-304