FALCONE Veronica

Prediction of Gestational Diabetes at Early Pregnancy from Labor Parameters of Glucose Metabolism at Fasting: a Prospective Study

Background: Gestational diabetes (GDM) is associated with severe consequences for both, mother and offspring, like secondary cesarean section, higher risk of developing diabetes mellitus II, macrosomia and fetal death. The early detection of pregnant women with higher risk of developing GDM would be beneficial to reduce morbidities and to begin an adequate therapy already at early pregnancy.

Materials and methods: Up to 700 pregnant women will be included in our investigation. A metabolic characterization will be performed before 15+6 weeks with fasting laboratory assessments of glucose (FPG), insulin (FI), C-peptide (FCP) and HbA1c. Thereafter, patients will be followed-up until delivery to evaluate status of GDM and need of pharmacotherapy. Sonographic assessment of fetal growth will be performed during pregnancy.

Aim of the study: This study aims to find out if fasting measurements of glucose, C-peptide and surrogate indices of glycemic condition can be used for risk stratification of pregnant women with high risk for GDM in early gestation, with the advantages of being cheap, less time consuming and simple. In addition, the correlation between fasting indices of glucose disposal and need of pharmacotherapy will be assessed.

Methods and Skills:

Glucose disposal laboratory parameters; clinical studies

Publications:

Falcone V, Stopp T, Feichtinger M, Kiss H, Eppel W, Husslein PW, Prager G, Göbl CS. Pregnancy after bariatric surgery: a narrative literature review and discussion of impact on pregnancy management and outcome. BMC Pregnancy Childbirth 18: 507, 2018

Yerlikaya G, Falcone V, Stopp T, Mittlböck M, Tura A, Husslein P, Eppel W, Göbl CS. To predict the requirement of pharmacotherapy by OGTT glucose levels in women with GDM classified by the IADPSG criteria. J Diabetes Res: 3243754, 2018

Curti A, Zucchini C, De Maggio I, Ismail YS, Morano D, Falcone V, Meriggiola MC, Farina A. Fetal cardiac defects and third-trimester maternal serum placental growth factor. Ultrasound Obstet Gynecol 45: 751-752, 2015

Contro E, Cha DH, De Maggio I, Ismail SY, Falcone V, Gabrielli S, Farina A. Uterine artery Doppler longitudinal changes in pregnancies complicated with intrauterine growth restriction without preeclampsia. Prenat Diagn 34: 1332-1336, 2014

Zucchini C, Montesanto I, Falcone V, Azzaroli F, Pittalis MC, Farina A. Intrahepatic cholestasis of pregnancy: mRNAs for LIPF and ELOVL4 genes are not detectable in circulating maternal plasma. Fetal Diagn Ther 38: 238-240, 2015