Prediction of Gestational Diabetes at Early Pregnancy from Labor Parameters of Glucose Metabolism at Fasting: a Prospective Study
Background: Gestational diabetes (GDM) is associated with severe consequences for both, mother and offspring, like secondary cesarean section, higher risk of developing diabetes mellitus II, macrosomia and fetal death. The early detection of pregnant women with higher risk of developing GDM would be beneficial to reduce morbidities and to begin an adequate therapy already at early pregnancy.
Materials and methods: Up to 700 pregnant women will be included in our investigation. A metabolic characterization will be performed before 15+6 weeks with fasting laboratory assessments of glucose (FPG), insulin (FI), C-peptide (FCP) and HbA1c. Thereafter, patients will be followed-up until delivery to evaluate status of GDM and need of pharmacotherapy. Sonographic assessment of fetal growth will be performed during pregnancy.
Aim of the study: This study aims to find out if fasting measurements of glucose, C-peptide and surrogate indices of glycemic condition can be used for risk stratification of pregnant women with high risk for GDM in early gestation, with the advantages of being cheap, less time consuming and simple. In addition, the correlation between fasting indices of glucose disposal and need of pharmacotherapy will be assessed.
Methods and Skills:
Glucose disposal laboratory parameters; clinical studies
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