Previous University and Subject: Medical University of Vienna / Human Medicine
Thesis since: 12/2016
Metabolic and Molecular Imaging for Characterization of Clinical Features and Their Change in the Course of Treatment in Patients with Acromegaly
Acromegaly is a rare disease with severe metabolic and musculoskeletal disturbances. We have recently shown, that patients with acromegaly exhibit inadequately low intracellular lipid content in the liver and the heart, which stands in sharp contrast to other insulin resistant states. Now we hypothesize that changes in mitochondrial oxidation capacity, de novo lipogenesis and VLDL secretion relate to ectopic lipid deposition in skeletal muscle and liver and aim to assess these alterations in the course of treatment and in comparison to healthy controls. Furthermore, molecular imaging should identify underlying mechanisms of the acromegalic tendinopathy.
This in-depth characterization of metabolic and musculoskeletal features may contribute the implementation of innovative diagnostic tools for therapy monitoring and the development of therapeutic approaches that target beneficial (anti-lipid deposition) and limit adverse (insulin resistance, tendinopathy) effects of acromegaly.
Aim 1: Assessment of the impact of GH on metabolic activity and ectopic lipid accumulation.
Aim 2: Assessment of the impact of insulin sensitivity on metabolic activity and ectopic lipid accumulation in acromegalic patients.
Aim 3: Assessment of de novo lipogenesis and VLDL-secretion by plasma fatty acid-, VLDL- and Apo-lipoprotein-profiling
Aim 4: Measurement of collagen- and gag-content in the Achilles tendon (by T2* and sodium MR-imaging)
Methods and Skills:
Clinical studies; magnetic resonance spectroscopy
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