KNOTZER Sophie Marie

Previous University and Subject: Veterinary University Vienna / Biomedicine & Biotechnology

Thesis since: 10/2021

Technical Devices and Metabolomics Will Direct Diabetes Care to Precision Medicine (TEAM) – A Registry and Biobank Study

The overarching aim of this study is the establishment of a prospective diabetes registry and biobank at the Medical University of Vienna that is based on metabolomic profiling, IDX-retina-scans and data from patients that undergo their annual follow-ups.
We hypothesize that with the help of metabolomics and the identification of biomarkers, risks for diabetes-related complications, drug-response mechanisms to antihyperglycemic agents or gender-specific differences can be predicted, and risk stratification for complications can be improved.
Moreover, we postulate that this study is based on the assumption that continuous glucose monitoring (CGM) profiles will directly show pharmacodynamic response to antihyperglycemic agents. Moreover, new algorithms could complement metabolomic findings and guide therapeutic decision making to an individualized level, also driving telemedical technologies forward.
Furthermore we presume that data obtained from patients during their routine clinical visits, including bioimpedance analyses for the determination of body composition, laboratory parameters, glycemia and newly implemented IDx-retina-scans, can aid in the characterization of specific forms of diabetes e.g. Latent Autoimmune Diabetes of Adulthood (LADA), Maturity-Onset Diabetes of the young (MODY).
Finally, we hypothesize that sex-specific requirements regarding disease progression and development of diabetes related complications or even therapeutical approaches, can be detected by the assessment of metabolic profiles, laboratory parameters or differences in CGM profiles, thereby highlighting the need for personalized therapeutic procedures and precision medicine.

Methods and Skills:

Publications:

Kovarik JJ, Antlanger M, Domenig O, Kaltenecker CC, Hecking M, Haidinger M, Werzowa J, Kopecky C, Säemann MD: Molecular regulation of the renin–angiotensin system in haemodialysis patients. Clin Endocrinol (Oxf). 78: 489-496, 2013