Supervisor: Christian Göbl
Committee: Johannes Ott, Michael Feichtinger
Department: Gynecology & Obstetrics, Division of Obstetrics and Feto-Maternal Medicine
Tel: +43 (0)1 40400 - 29380
Current academic degree: M.D.
Previous University and Subject: Medical University of Vienna, Human Medicine
Thesis since: 09/2021
With a worldwide surge of women affected by overweight or obesity (OW/OB), gestational diabetes mellitus (GDM) also increases, with a global prevalence of around 14%. The consequence of chronic maternal hyperglycemia is an increased fetal weight with subsequent obstetric complications and an elevated risk for childhood obesity and type 2 diabetes in the offspring. OW/OB is a strong risk factors for GDM, and in the presence of GDM, OW/OB increases the risk for adverse pregnancy outcomes. Studies have shown that OW/OB alone is an independent risk factor for early pregnancy loss, large for gestational age new-borns, preeclampsia and intrauterine fetal death. Only scarce data is available on the outcome of small-for-gestational age fetuses of obese women with GDM.
OW/OB is difficult to treat, and bariatric surgery seems to yield the best long-term results. A growing number of pregnancies after bariatric surgery can be seen. However, the effects of bariatric surgery on maternal glucose metabolism, pregnancy outcomes and fetal and neonatal development have not been studied thoroughly yet. The aims of this thesis project are to assess:
- differences in glucose metabolism in pregnancies affected by OW/OB compared to normal weight controls with a special focus on different obesity phenotypes and fetal growth restriction
- differences in glycaemic control between OW/OB and normal weight pregnancies affected by GDM using continuous glucose management systems
- the effect of bariatric surgery on maternal glucose metabolism and pregnancy outcome
Linder T, Dressler-Steinbach I, Tura A, Göbl C. New developments, challenges and open questions in diagnosis and treatment of gestational diabetes mellitus. J Clin Med 11: 7197, 2022
Linder T, Eppel D, Kotzaeridi G, Rosicky I, Yerlikaya-Schatten G, Kiss H, Weißhaupt K, Henrich W, Bozkurt L, Tura A, Roden M, Göbl CS. Fatty liver indices and their association with glucose metabolism in pregnancy - An observational cohort study. Diabetes Res Clin Pract 189: 109942, 2022
Linder T, Eder A, Monod C, Rosicky I, Eppel D, Redling K, Geissler F, Huhn EA, Hösli I, Göbl CS. Impact of prepregnancy overweight and obesity on treatment modality and pregnancy outcome in women with gestational diabetes mellitus. Front Endocrinol (Lausanne) 13: 799625, 2022
and several other publications