STEINACHER Daniel

Previous University and Subject: Medical University of Vienna, Human Medicine

Thesis since: 10/2013

Characterization of Metabolic and Therapeutic Properties of Modified Bile Acid Derivatives

Prevalence of nonalcoholic fatty liver disease (NAFLD) - a spectrum of liver diseases ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) leading to liver cirrhosis and hepatocellular carcinoma (HCC) - is increasing. Bile acids (BA) could constitute a new therapeutic option. BA can improve liver damages in a mouse model for liver diseases by stimulating biliary HCO3 secretion, reducing inflammation, fibrosis and apoptosis. Therefore, we want to investigate bile acids in mouse models of liver diseases.

Methods and Skills:

Western blot; histology; real time PCR; metabolic cages