Supervisor: Michael Trauner
Committee: Michael Krebs, Harald Esterbauer
Department: Internal Medicine III, Clinical Division of Hepatology
E-mail: daniel.steinacher@meduniwien.ac.at
Tel: +43 (0)1 40400 - 61590
Homepage: http://www.meduniwien.ac.at/innere3/
Current academic degree: Cand.med.
Previous University and Subject: Medical University of Vienna, Human Medicine
Thesis since: 10/2013
Prevalence of nonalcoholic fatty liver disease (NAFLD) - a spectrum of liver diseases ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) leading to liver cirrhosis and hepatocellular carcinoma (HCC) - is increasing. Bile acids (BA) could constitute a new therapeutic option. BA can improve liver damages in a mouse model for liver diseases by stimulating biliary HCO3 secretion, reducing inflammation, fibrosis and apoptosis. Therefore, we want to investigate bile acids in mouse models of liver diseases.
Western blot; histology; real time PCR; metabolic cages