BISCHOF Martin, M.D.

Research Interests: In vivo studies of fuel metabolism, pathophysiology of hypoglycemia couterregulation in diabetes

MR spectroscopy is a unique tool to study substrate metabolism in humans. Without invasive sampling the concentration of different metabolites can be measured in muscle, brain, and liver. Thus, it becomes possible to study the changes of substrate metabolism during systemic modifications of insulin and glucose levels over a prolonged period of time. With advanced MR techniques such as saturation transfer even intracellular flux rats of metabolites can be quantified.

Methods & Techniques

Human in vivo studies; clamp techniques (hypoglycemic, euglycemic) to achieve defined states of glycemia; in vivo MR spectroscopy to study glucose and substrate metabolism in muscle, brain, and liver

Selected Publications

Weghuber D, Mandl M, Krssak M, Roden M, Nowotny P, Brehm A, Krebs M, Widhalm K, Bischof MG. Characterization of hepatic and brain metabolism in young adults with glycogen storage disease type I – a magnetic resonance spectroscopy study. American Journal of Physiology - Endocrinology and Metabolism 293: E1378-E1384, 2007

Bischof MG, Brehm A, Bernroider E, Krssak M, Mlynarik V, Krebs M, Roden M. Cerebral glutamate metabolism during hypoglycemia in healthy and type 1 diabetic humans. European Journal of Clinical Investigation 36: 164-169, 2006

Bischof MG, Mlynarik V, Brehm A, Bernroider E, Krssak M, Bauer E, Madl C, Waldhäusl W, Roden M. Brain energy metabolism during hypoglycemia in healthy and type 1 diabetic humans. Diabetologia 47: 648-651, 2004

Bischof MG, Bernroider E, Krssak M, Krebs M, Stingl H, Nowotny P, Yu C, Shulman GI, Waldhäusl W, Roden M. Hepatic glycogen metabolism in type 1 diabetes after long-term near normoglycemia. Diabetes 51: 49-54, 2002

Bischof MG, Bernroider E, Ludwig C, Kurzemann S, Kletter K, Waldhäusl W, Roden M. Effect of near physiologic insulin therapy on hypoglycemia counterregulation in type 1 diabetes. Hormone Research 56: 151-158, 2001

Bischof MG, Krssak M, Krebs M, Bernroider E, Stingl H, Waldhäusl W, Roden M. Effects of short-term improvement of insulin treatment and glycemia on hepatic glycogen metabolism in type 1 diabetes mellitus. Diabetes 50: 392-398, 2001

Bischof M, Ludwig C, Hofer A, Kletter K, Krebs M, Stingl H, Nowotny P, Waldhäusl W, Roden M. Hormonal and metabolic counterregulation during and after high-dose insulin-induced hypoglycemia in diabetes mellitus type 2. Hormone and Metabolic Research 32: 417-423, 2000