KREBS Michael, M.D.

Research Interests: Pathophysiology of Fuel Metabolism, Magnetic Resonance Spectroscopy, Diabetes and Endocrinology

During the recent years we have performed studies on glucose metabolism in normal volunteers and diabetic subjects using NMR spectroscopy (non-invasive determination of glycogen concentrations in skeletal muscle and liver, muscular glucose-6-phosphate, and intracellular lipids). Our group also applies various tracer techniques and biopsies of skeletal muscle in combination with hyperinsulinemic- and pancreatic-clamp tests to determine rates of glucose turnover, gluconeogenesis, and molecular mechanisms insulin resistance. I am especially interested in elucidating the mechanisms of nutrient induced insulin resistance in humans. A major focus of my research work was the pathogenesis of vascular and myocardial disease associated with the insulin resistance syndrome and type 2 diabetes.

Methods & Techniques

NMR spectroscopy; tracer techniques; biopsies of skeletal muscle; hyperinsulinemic- and pancreatic clamp tests

Selected Publications

Krebs M, Krssak M, Weghuber D, Nowotny P, Gruber S, Mlynarik V, Bischof MG, Stingl H, Fürnsinn C, Waldhäusl W, Roden M. Free fatty acids inhibit the glucose-stimulated increases of intramuscular glucose-6-phosphate concentrations in man. J Clin Endocrinol Metab 86: 2153-2160, 2001

Krebs M, Krssak M, Bernroider E, Nowotny P, Anderwald C, Brehm A, Roth E, Waldhäusl W, Roden M. Mechanism of amino acid-induced skeletal muscle insulin resistance in humans. Diabetes 51: 599-605, 2002

Krebs M, Brehm A, Krssak M, Anderwald C, Bernroider E, Nowotny P, Roth E, Chandramouli V, Landau BR, Waldhäusl W, Roden M. Direct and indirect effects of amino acids on hepatic glucose metabolism. Diabetologia 46: 917-925, 2003

Krebs M, Geiger M, Polak K, Vales A, Schmetterer L, Waldhäusl W, Binder BR, Roden M. Increased plasma levels of plasminogen activator inhibitor-1 and soluble vascular cell adhesion molecule after triacylglycerol infusion in man. Thromb Heamostas 90: 422-428, 2003

Tremblay F, Krebs M, Dombrowski L,  Brehm A, Bernroider E, Roth E, Novotny P, Waldhäusl W, Marette A, Roden M. Overactivation of S6K1: Overactivation of S6K1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 54: 2674-84, 2005

Krebs M, Brunmair B, Brehm A, Artwohl M, Szendrödi J, Nowotny P, Roth E, Fürnsinn C, Promintzer M, Anderwald C, Bischof M, Roden M. The mTOR-pathway regulates nutrient sensitive glucose uptake in man. Diabetes 56: 1600-1607, 2007

Anderwald C, Anderwald-Stadler M, Promintzer M, Prager G, Mandl M, Nowotny P, Bischof MG, Wolzt M, Ludvik B, Kästenbauer T, Pacini G, Luger A, Krebs M. Clamp-like Index: a Novel, Highly Sensitive Insulin Sensitivity Index to Calculate Hyperinsulinemic Clamp Glucose Infusion Rates from Oral Glucose Tolerance Test in Nondiabetic Humans. Diabetes Care 30: 2374-2380, 2007

Stadler M, Anderwald C, Zbyn S, Pacini G, Promintzer-Schifferl M, Mandl M, Bischof M, Gruber S, Nowotny P, Luger A, Prager R, Krebs M. Peripheral hyperinsulinemia does not induce tissue lipid accumulation in type 1 diabetic patients after successful combined pancreas kidney transplantation. Diabetes 59: 215-218, 2010

Anderwald C, Stadler M, Golay A, Krebs M, Petrie J, Luger A; on behalf of the RISC Investigators. Impact of family history on relationships among insulin resistance, LDL cholesterol and carotid IMT in healthy adults. Heart 96: 1191-1200, 2010

M. Krššák, Y. Winhofer, C. Göbl, M. Bischof, G. Reiter,A. Kautzky-Willer, A. Luger, M. Krebs, C. Anderwald. Insulin resistance is not associated with myocardial steatosis in women. Diabetologia 54: 1871-1878, 2011