PIETSCHMANN Peter, M.D.

E-Mail: peter.pietschmann@meduniwien.ac.at

Homepage: www.meduniwien.ac.at/hp/ipa/forschung/forschungsgruppen/bone-gender-and-aging-research/

Research Interests: Biology and Pathophysiology of Bone, Osteoimmunology

• Relation of bone strength to gene expression; genetics of bone fragility
• Microarchitecture of bone in female versus male osteoporosis
• Transgenic and other animal models for the study of bone diseases
• Immune cells and cytokines in the pathogenesis of osteoporosis in women and men
• Impact of inflammation on the generation and function of osteoblasts and osteoclasts
• Inflammaging and bone fragility
• Effects of vitamin D in the immune system

Methods & Techniques

Cell culture; molecular biology; protein chemistry; bone histomorphometry; micro CT of bone tissue; flow cytometry.

Selected Publications

Patsch JM, Kohler T, Berzlanovich A, Muschitz C, Bieglmayr C, Roschger P, Resch H Pietschmann P. Trabecular bone microstructure and local gene expression in iliac crest biopsies of men with idiopathic osteoporosis. J Bone Miner Res 26: 1584-1592, 2011

Rauner M, Sipos W, Göttsch C, Wutzl A, Foisner R, Pietschmann P, Hofbauer LC  Inhibition of lamin A/C attenuates osteoblast differentiation and enhances RANKL-dependent osteoclastogenesis. J Bone Miner Res,24: 78-86, 2009

Orwoll E, Ettinger M, Weiss S, Miller P, Kendler D, Graham J, Adami S, Weber K, Lorenc R, Pietschmann P, Silverman S, Felsenberg D, Vandormael K, Daifotis A, Lombardi A. Alendronate treatment of osteoporosis in men. N Engl J Med 343: 604-610, 2000

Pietschmann P, Cush JJ, Lipsky PE, Oppenheimer Marks N. Identification of subsets of human T cells capable of enhanced transendothelial migration. J Immunol 149: 1170-1178, 1992

Rauner M, Stupphann D, Haas M., Fert I, Glatigny S, Sipos W, Breban M, Pietschmann P. The HLA-B27 transgenic rat, a model of spondyloarthritis, has a decreased bone mineral density and an increased RANKL-to-OPG mRNA ratio. J Rheumatol 36: 120-126, 2009