• Research to provide a scientific basis to improve and extend the Austrian Newborn Screening
o Adapting the list of screened diseases including development of new assays and novel strategies including, e.g., screening for severe combined immunodeficiency (SCID).
o Improvement of the analyses, mainly to reduce the false positive rate that causes stress and anxiety of the parents mainly by development and implementation of so called “second-tier”-testing.
o Coping with the problem of the increased number of preterm newborns, which differ in many parameters to mature newborns
• Research on rare diseases also in later life.
Many rare, in particular metabolic, diseases remain undetected and untreated due to lack of knowledge and lack of proper diagnosis.
• Research on the relationship between inflammation and metabolic diseases.
Inflammation by now is known to be a cause for various diseases. The major risk factor for the development of type 2 diabetes and other metabolic diseases is obesity, which in turn is associated with a variety of immunological complications. The pathophysiological role of the innate as well the adaptive immune system and respective treatment strategies for metabolic disease are addressed by several approaches.
Methods & Techniques
The equipment of our lab allows the use of a large variety of techniques such as HPLC-MS; enzymatic assays; quantitative real-time PCR; tissue culture; diverse cellular, biochemical and immunological assays; flow cytometry; molecular and cell biology.biology
Leitner L, Jürets A, Itariu BK, Keck M, Prager G, Langer F, Grablowitz V, Zeyda M, Stulnig TM. Osteopontin promotes aromatase expression and estradiol production in human adipocytes. Breast Cancer Res Treat 2015 Oct 20 [Epub ahead of print]2011
Neuhofer A, Zeyda M, Mascher D, Itariu BK, Murano I, Leitner L, Hochbrugger EE, Fraisl P, Cinti S, Serhan CN, Stulnig TM. Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. Diabetes 62: 1945-1956, 2013
Zeyda M, Wernly B, Demyanets S, Kaun C, Hammerle M, Hantusch B, Schranz M, Neuhofer A, Itariu BK, Keck M, Prager G, Wojta J, Stulnig TM. Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue. Int J Obes (Lond) 37: 658-65, 2013