The Christian Doppler Laboratory for Radiation Research for Radiation Oncology combines joint research activities in radiation biology and physical/technological developments in functional imaging and adaptive radiotherapy with particular emphasis on application to ion-beam versus conventional, high quality photon beam therapy.
Workpackage 1 "Multimodality and Functional Imaging" contributes to the goals and visions of the CD Laboratory through improved understanding of the therapy response and the underlying biology on which treatment adaptations may be founded.
Workpackage 2 "Image Guided Adaptive Radiation Therapy (IGART)" has the aim to optimize dose delivery by taking into account intra-and inter-fractional image data, both with respect ot space and time as well as by including radiobiological information.
Workpackage 3 "Tumor and Normal Tissue Radiobiology" encompasses two major areas, the pre-clinical studies in normal tissue models in experimental animals and clinical investigations on treatment outcome and normal tissue side effects in strong collaboration with Workpackage 2.
Workpackage 4 " Ion Beam Therapy" focuses on the transformation and integration of research outcome on image guided approaches and biologically adaptive radiotherapy (IGAIT) using photons into ion beam therapy. Ion-beam therapy has not benefited adequately from latest image guidance developments, hence the results and experience from WP2 with a focus on advanced photon therapy provides an ideal link for WP4. Moreover the characterization of novel ion species is an important research topic in workpackage 4. Besides the aspects of dose calculation and optimization, studies on treatment plan comparison and treatment plan robustness are pursued.