Aims of the SFB (2013 - 2021) were
- Identification and validation of genetic and epigenetic factors and patterns as well as somatic lesions and mutational profiles underlying evolution, progression, and drug-resistance in various MPN and to study the functional and clinical impact of individual (identified) lesions, of mutation patterns, and of relevant genetic (germline) background factors. Gender-related mechanisms and familial clustering of MPN will also be analyzed.
- Defining critical cellular hierarchies (LSC) and cellular interactions relevant to disease manifestation, clonal evolution, sub-clone formation/expansion, as well as progression and resistance in MPN.
- Identification of major signaling molecules and networks as well as key effector molecules involved in the regulation of growth, survival and resistance of neoplastic cells and MPN-initiating LSC in various MPN.
- Identification of new relevant therapeutic targets and critical target networks in various MPN, as well as exploring optimal ways and strategies of targeting neoplastic (stem) cells in MPN.