2013 - 2017
Epigenetic Mechanisms involved in Disease Manifestation and Progression in MPN.
The project part leader, Sabine Zöchbauer-Müller, is group leader and Program Director for Molecular Targeting and Epigenetics at the Department of Medicine I (Division of Oncology) of the Medical University of Vienna. Sabine is a well-known expert in the field of tumor suppressor genes (TSG) in oncology. Her group has a major interest in epigenetic regulation of neoplastic cells and the identification and validation of clinically relevant TSG and related drug targets in diverse malignancies.
In the SFB from 2013 to 2017, her team focused on epigenetic mechanisms and targets relevant to growth and survival of neoplastic cells in various MPN.
Sabine’s group focused on the effects of MPN-related driver-mutants on DNA methylation and TSG expression. In addition, project #09 examined the effects of various targeted drugs on MPN cells and the mechanisms underlying antineoplastic drug effects.