Publikationsliste der Abteilung

2018

The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma.
Laszlo V, Valko Z, Ozsvar J, Kovacs I, Garay T, Hoda MA, Klikovits T, Stockhammer P, Aigner C, Gröger M, Klepetko W, Berger W, Grusch M, Tovari J, Waizenegger IC, Dome B, Hegedus B.J Mol Med (Berl). 2019 Feb;97(2):231-242. doi: 10.1007/s00109-018-1725-7. Epub 2018 Dec 11.PMID: 30539198

Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis.
Korfei M, Stelmaszek D, MacKenzie B, Skwarna S, Chillappagari S, Bach AC, Ruppert C, Saito S, Mahavadi P, Klepetko W, Fink L, Seeger W, Lasky JA, Pullamsetti SS, Krämer OH, Guenther A.PLoS One. 2018 Nov 27;13(11):e0207915. doi: 10.1371/journal.pone.0207915. eCollection 2018.PMID: 30481203

Increased serum concentrations of soluble ST2 predict mortality after burn injury.
Hacker S, Dieplinger B, Werba G, Nickl S, Roth GA, Krenn CG, Mueller T, Ankersmit HJ, Haider T.Clin Chem Lab Med. 2018 Nov 27;56(12):2079-2087. doi: 10.1515/cclm-2018-0042.PMID: 29949506

Subcutaneous treprostinil for the treatment of severe non-operable chronic thromboembolic pulmonary hypertension (CTREPH): a double-blind, phase 3, randomised controlled trial.
Sadushi-Kolici R, Jansa P, Kopec G, Torbicki A, Skoro-Sajer N, Campean IA, Halank M, Simkova I, Karlocai K, Steringer-Mascherbauer R, Samarzija M, Salobir B, Klepetko W, Lindner J, Lang IM.Lancet Respir Med. 2019 Mar;7(3):239-248. doi: 10.1016/S2213-2600(18)30367-9. Epub 2018 Nov 23.PMID: 30477763

New insights into the impact of primary lung adenocarcinoma location on metastatic sites and sequence: A multicenter cohort study.
Klikovits T, Lohinai Z, Fábián K, Gyulai M, Szilasi M, Varga J, Baranya E, Pipek O, Csabai I, Szállási Z, Tímár J, Hoda MA, Laszlo V, Hegedűs B, Renyi-Vamos F, Klepetko W, Ostoros G, Döme B, Moldvay J.Lung Cancer. 2018 Dec;126:139-148. doi: 10.1016/j.lungcan.2018.11.004. Epub 2018 Nov 5.PMID: 30527178

Torque Teno Virus as a Novel Biomarker Targeting the Efficacy of Immunosuppression After Lung Transplantation.
Jaksch P, Kundi M, Görzer I, Muraközy G, Lambers C, Benazzo A, Hoetzenecker K, Klepetko W, Puchhammer-Stöckl E.J Infect Dis. 2018 Nov 5;218(12):1922-1928. doi: 10.1093/infdis/jiy452.PMID: 30053048

Mutational profile of colorectal cancer lung metastases and paired primary tumors by targeted next generation sequencing: implications on clinical outcome after surgery.
Schweiger T, Liebmann-Reindl S, Glueck O, Starlinger P, Laengle J, Birner P, Klepetko W, Pils D, Streubel B, Hoetzenecker K.J Thorac Dis. 2018 Nov;10(11):6147-6157. doi: 10.21037/jtd.2018.10.72.PMID: 30622786

Mechanism of anti-remodelling action of treprostinil in human pulmonary arterial smooth muscle cells.
Lambers C, Kornauth C, Oberndorfer F, Boehm PM, Tamm M, Klepetko W, Roth M.PLoS One. 2018 Nov 1;13(11):e0205195. doi: 10.1371/journal.pone.0205195. eCollection 2018.PMID: 30383775

Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis.
Kwapiszewska G, Gungl A, Wilhelm J, Marsh LM, Thekkekara Puthenparampil H, Sinn K, Didiasova M, Klepetko W, Kosanovic D, Schermuly RT, Wujak L, Weiss B, Schaefer L, Schneider M, Kreuter M, Olschewski A, Seeger W, Olschewski H, Wygrecka M.Eur Respir J. 2018 Nov 22;52(5):1800564. doi: 10.1183/13993003.00564-2018. Print 2018 Nov.PMID: 30166321 

Cardiac and Pulmonary Cystic Echinococcosis With Massive Obstruction of the Pulmonary Vessel System in a 16-Year-Old Girl.
Kohlmaier B, Trobisch A, Pfurtscheller K, Knez I, Klepetko W, Pilhatsch A, Schweintzger S, Zenz W.Pediatr Infect Dis J. 2018 Nov;37(11):e273-e275. doi: 10.1097/INF.0000000000002066.PMID: 29634619

Chronic Thromboembolic Pulmonary Hypertension and Antiphospholipid Syndrome with Immune Thrombocytopenia: A Case Report.
Skride A, Sablinskis M, Sablinskis K, Lejniece S, Lejnieks A, Klepetko W, Lang IM.Am J Case Rep. 2018 Oct 19;19:1245-1248. doi: 10.12659/AJCR.909778.PMID: 30337514

Myostatin and other musculoskeletal markers in lung transplant recipients.
Kerschan-Schindl K, Ebenbichler G, Gruther W, Föger-Samwald U, Kudlacek S, Patsch J, Gleiss A, Jaksch P, Klepetko W, Pietschmann P.Clin Exp Med. 2019 Feb;19(1):77-85. doi: 10.1007/s10238-018-0532-3. Epub 2018 Oct 13.PMID: 30317402

Docking of Meprin α to Heparan Sulphate Protects the Endothelium from Inflammatory Cell Extravasation.
Biasin V, Wygrecka M, Bärnthaler T, Jandl K, Jain PP, Bálint Z, Kovacs G, Leitinger G, Kolb-Lenz D, Kornmueller K, Peters F, Sinn K, Klepetko W, Heinemann A, Olschewski A, Becker-Pauly C, Kwapiszewska G.Thromb Haemost. 2018 Oct;118(10):1790-1802. doi: 10.1055/s-0038-1670657. Epub 2018 Sep 20.PMID: 30235485

Intraoperative extracorporeal support during lung transplantation in patients bridged with venovenous extracorporeal membrane oxygenation.
Hashimoto K, Hoetzenecker K, Yeung JC, Jeagal L, Donahoe L, Pierre A, de Perrot M, Yasufuku K, Waddell TK, Keshavjee S, Cypel M.J Heart Lung Transplant. 2018 Dec;37(12):1418-1424. doi: 10.1016/j.healun.2018.07.003. Epub 2018 Sep 5.PMID: 30193763

Chronic thromboembolic pulmonary hypertension (CTEPH): Updated Recommendations from the Cologne Consensus Conference 2018.
Wilkens H, Konstantinides S, Lang IM, Bunck AC, Gerges M, Gerhardt F, Grgic A, Grohé C, Guth S, Held M, Hinrichs JB, Hoeper MM, Klepetko W, Kramm T, Krüger U, Lankeit M, Meyer BC, Olsson KM, Schäfers HJ, Schmidt M, Seyfarth HJ, Ulrich S, Wiedenroth CB, Mayer E.Int J Cardiol. 2018 Dec 1;272S:69-78. doi: 10.1016/j.ijcard.2018.08.079. Epub 2018 Aug 28.PMID: 30195840 

Patient-specific, 3-dimensionally engineered silicone Y-stents in tracheobronchomalacia: Clinical experience with a novel type of airway stent.
Schweiger T, Gildea TR, Prosch H, Lang G, Klepetko W, Hoetzenecker K.J Thorac Cardiovasc Surg. 2018 Nov;156(5):2019-2021. doi: 10.1016/j.jtcvs.2018.06.049. Epub 2018 Jul 18.PMID: 30104064

Role of (myo)fibroblasts in the development of vascular and connective tissue structure of the C38 colorectal cancer in mice.
Bugyik E, Szabó V, Dezső K, Rókusz A, Szücs A, Nagy P, Tóvári J, László V, Döme B, Paku S.Cancer Commun (Lond). 2018 Jul 5;38(1):46. doi: 10.1186/s40880-018-0316-x.PMID: 29976246

Pre-emptive glottic enlargement before laryngotracheal surgery in patients at high risk for postoperative bilateral vocal fold paralysis.
Schweiger T, Hoetzenecker K, Roesner I, Schneider-Stickler B, Denk-Linnert DM, Klepetko W.Eur J Cardiothorac Surg. 2018 Jul 1;54(1):106-112. doi: 10.1093/ejcts/ezx511.PMID: 29401237

Afatinib restrains K-RAS-driven lung tumorigenesis.
Moll HP, Pranz K, Musteanu M, Grabner B, Hruschka N, Mohrherr J, Aigner P, Stiedl P, Brcic L, Laszlo V, Schramek D, Moriggl R, Eferl R, Moldvay J, Dezso K, Lopez-Casas PP, Stoiber D, Hidalgo M, Penninger J, Sibilia M, Győrffy B, Barbacid M, Dome B, Popper H, Casanova E.Sci Transl Med. 2018 Jun 20;10(446):eaao2301. doi: 10.1126/scitranslmed.aao2301.PMID: 29925635

DNA methylation of microRNA-coding genes in non-small-cell lung cancer patients.
Heller G, Altenberger C, Steiner I, Topakian T, Ziegler B, Tomasich E, Lang G, End-Pfützenreuter A, Zehetmayer S, Döme B, Arns BM, Klepetko W, Zielinski CC, Zöchbauer-Müller S.J Pathol. 2018 Aug;245(4):387-398. doi: 10.1002/path.5079. Epub 2018 Jun 20.PMID: 29570800 

The influence of retransplantation on survival for pediatric lung transplant recipients.
Waseda R, Benazzo A, Hoetzenecker K, Jaksch P, Muraközy G, Gruber S, Roth G, Szépfalusi Z, Nachbaur E, Klepetko W.J Thorac Cardiovasc Surg. 2018 Nov;156(5):2025-2034.e2. doi: 10.1016/j.jtcvs.2018.05.080. Epub 2018 Jun 6.PMID: 30343700 

Effect of antifibrotics on short-term outcome after bilateral lung transplantation: a multicentre analysis.
Lambers C, Boehm PM, Lee S, Ius F, Jaksch P, Klepetko W, Tudorache I, Ristl R, Welte T, Gottlieb J.Eur Respir J. 2018 Jun 21;51(6):1800503. doi: 10.1183/13993003.00503-2018. Print 2018 Jun.PMID: 29678942

Feasibility and Reliability of Functional Muscle Tests in Lung Transplant Recipients.
Kienbacher T, Achim-Gunacker G, Pachner M, Kerschan-Schindl K, Gunacker P, Habenicht R, Klepetko W, Jaksch P, Doblhammer S, Ebenbichler G.Am J Phys Med Rehabil. 2018 Jun;97(6):390-396. doi: 10.1097/PHM.0000000000000849.PMID: 29016397 

Subglottic Resections: How I Teach It.
Hoetzenecker K, Klepetko W.Ann Thorac Surg. 2018 Jul;106(1):1-7. doi: 10.1016/j.athoracsur.2018.05.001. Epub 2018 May 22.PMID: 29792830

Impact of nutritional status on pulmonary function after lung transplantation for cystic fibrosis.
Staufer K, Halilbasic E, Hillebrand P, Harm S, Schwarz S, Jaksch P, Kivaranovic D, Klepetko W, Trauner M, Kazemi-Shirazi L.United European Gastroenterol J. 2018 Aug;6(7):1049-1055. doi: 10.1177/2050640618778381. Epub 2018 May 17.PMID: 30228893

Lung allocation score: the Eurotransplant model versus the revised US model - a cross-sectional study.
Smits JM, Nossent G, Evrard P, Lang G, Knoop C, Kwakkel-van Erp JM, Langer F, Schramm R, van de Graaf E, Vos R, Verleden G, Rondelet B, Hoefer D, Hoek R, Hoetzenecker K, Deuse T, Strelniece A, Green D, de Vries E, Samuel U, Laufer G, Buhl R, Witt C, Gottlieb J.Transpl Int. 2018 Aug;31(8):930-937. doi: 10.1111/tri.13262. Epub 2018 May 11.PMID: 29665090

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells.
Molnár E, Rittler D, Baranyi M, Grusch M, Berger W, Döme B, Tóvári J, Aigner C, Tímár J, Garay T, Hegedűs B.BMC Cancer. 2018 May 8;18(1):542. doi: 10.1186/s12885-018-4455-x.PMID: 29739364

Nintedanib Is Active in Malignant Pleural Mesothelioma Cell Models and Inhibits Angiogenesis and Tumor Growth In Vivo.
Laszlo V, Valko Z, Kovacs I, Ozsvar J, Hoda MA, Klikovits T, Lakatos D, Czirok A, Garay T, Stiglbauer A, Helbich TH, Gröger M, Tovari J, Klepetko W, Pirker C, Grusch M, Berger W, Hilberg F, Hegedus B, Dome B.Clin Cancer Res. 2018 Aug 1;24(15):3729-3740. doi: 10.1158/1078-0432.CCR-17-1507. Epub 2018 May 3.PMID: 29724868

Controversies in oncology: surgery for small cell lung cancer? It's time to rethink the case.
Hoda MA, Klikovits T, Klepetko W.ESMO Open. 2018 Apr 27;3(3):e000366. doi: 10.1136/esmoopen-2018-000366. eCollection 2018.PMID: 29719730

Usefulness of thrombosis and inflammation biomarkers in chronic thromboembolic pulmonary hypertension-sampling plasma and surgical specimens.
Skoro-Sajer N, Gerges C, Gerges M, Panzenböck A, Jakowitsch J, Kurz A, Taghavi S, Sadushi-Kolici R, Campean I, Klepetko W, Celermajer DS, Lang IM.J Heart Lung Transplant. 2018 Sep;37(9):1067-1074. doi: 10.1016/j.healun.2018.04.003. Epub 2018 Apr 25.PMID: 2980208

Increased serum concentrations of soluble ST2 are associated with pulmonary complications and mortality in polytraumatized patients.
Haider T, Simader E, Hacker P, Ankersmit HJ, Heinz T, Hajdu S, Negrin LL.Clin Chem Lab Med. 2018 Apr 25;56(5):810-817. doi: 10.1515/cclm-2017-0762.PMID: 29341938

Prognostic and diagnostic impact of fibrinogen, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio on thymic epithelial tumors outcome.
Janik S, Raunegger T, Hacker P, Ghanim B, Einwallner E, Müllauer L, Schiefer AI, Moser J, Klepetko W, Ankersmit HJ, Moser B.Oncotarget. 2018 Apr 24;9(31):21861-21875. doi: 10.18632/oncotarget.25076. eCollection 2018 Apr 24.PMID: 29774108

Chemotherapy treatment is associated with altered PD-L1 expression in lung cancer patients.
Rojkó L, Reiniger L, Téglási V, Fábián K, Pipek O, Vágvölgyi A, Agócs L, Fillinger J, Kajdácsi Z, Tímár J, Döme B, Szállási Z, Moldvay J.J Cancer Res Clin Oncol. 2018 Jul;144(7):1219-1226. doi: 10.1007/s00432-018-2642-4. Epub 2018 Apr 19.PMID: 29675791

FGF2 and EGF induce epithelial-mesenchymal transition in malignant pleural mesothelioma cells via a MAPKinase/MMP1 signal.
Schelch K, Wagner C, Hager S, Pirker C, Siess K, Lang E, Lin R, Kirschner MB, Mohr T, Brcic L, Marian B, Holzmann K, Grasl-Kraupp B, Krupitza G, Laszlo V, Klikovits T, Dome B, Hegedus B, Garay T, Reid G, van Zandwijk N, Klepetko W, Berger W, Grusch M, Hoda MA.Carcinogenesis. 2018 Apr 5;39(4):534-545. doi: 10.1093/carcin/bgy018.PMID: 29635378

Low-quality lower lobes-discard, repair, or only use the good rest?
Hoetzenecker K, Klepetko W.J Thorac Cardiovasc Surg. 2018 Jul;156(1):e39-e40. doi: 10.1016/j.jtcvs.2018.03.106. Epub 2018 Apr 3.PMID: 29754795

Reshaping a multimode laser beam into a constructed Gaussian beam for generating a thin light sheet.
Saghafi S, Haghi-Danaloo N, Becker K, Sabdyusheva I, Foroughipour M, Hahn C, Pende M, Wanis M, Bergmann M, Stift J, Hegedus B, Dome B, Dodt HU.J Biophotonics. 2018 Jun;11(6):e201700213. doi: 10.1002/jbio.201700213. Epub 2018 Mar 24.PMID: 29457696

PD-L1 expression is an independent predictor of favorable outcome in patients with localized esophageal adenocarcinoma.
Kollmann D, Ignatova D, Jedamzik J, Chang YT, Jomrich G, Baierl A, Kazakov D, Michal M, French LE, Hoetzenecker W, Schatton T, Asari R, Preusser M, Gnant M, Guenova E, Schoppmann SF.Oncoimmunology. 2018 Mar 13;7(6):e1435226. doi: 10.1080/2162402X.2018.1435226. eCollection 2018.PMID: 29872575

Resident cell lineages are preserved in pulmonary vascular remodeling.
Crnkovic S, Marsh LM, El Agha E, Voswinckel R, Ghanim B, Klepetko W, Stacher-Priehse E, Olschewski H, Bloch W, Bellusci S, Olschewski A, Kwapiszewska G.J Pathol. 2018 Apr;244(4):485-498. doi: 10.1002/path.5044. Epub 2018 Mar 9.PMID: 29359814

Author Correction: Down-regulated GATA-1 up-regulates interferon regulatory factor 3 in lung adenocarcinoma.
Wang LL, Chen ZS, Zhou WD, Shu J, Wang XH, Jin R, Zhuang LL, Hoda MA, Zhang H, Zhou GP.Sci Rep. 2018 Mar 6;8(1):4299. doi: 10.1038/s41598-018-22517-0.PMID: 29511303

ISHLT Consensus Statement on adult and pediatric airway complications after lung transplantation: Definitions, grading system, and therapeutics.
Crespo MM, McCarthy DP, Hopkins PM, Clark SC, Budev M, Bermudez CA, Benden C, Eghtesady P, Lease ED, Leard L, D'Cunha J, Wigfield CH, Cypel M, Diamond JM, Yun JJ, Yarmus L, Machuzak M, Klepetko W, Verleden G, Hoetzenecker K, Dellgren G, Mulligan M.J Heart Lung Transplant. 2018 May;37(5):548-563. doi: 10.1016/j.healun.2018.01.1309. Epub 2018 Feb 7.PMID: 29550149

Chylothorax in a 32-Year-Old Patient With Lymphangioleiomyomatosis After Bilateral Lung Transplant.
Boehm PM, Ghanim BD, Matilla J, Klepetko W, Taghavi S.Ann Thorac Surg. 2018 Jun;105(6):e263-e264. doi: 10.1016/j.athoracsur.2017.12.042. Epub 2018 Feb 2.PMID: 29408242

Malignant pleural mesothelioma-the impact of globalization on rare diseases.
Hoda MA, Ploenes T, Aigner C.J Thorac Dis. 2018 Feb;10(2):638-640. doi: 10.21037/jtd.2017.12.139.PMID: 29607128

Treprostinil inhibits proliferation and extracellular matrix deposition by fibroblasts through cAMP activation.
Lambers C, Roth M, Jaksch P, Muraközy G, Tamm M, Klepetko W, Ghanim B, Zhao F.Sci Rep. 2018 Jan 18;8(1):1087. doi: 10.1038/s41598-018-19294-1.PMID: 29348469

The inflammatory cell landscape in the lungs of patients with idiopathic pulmonary arterial hypertension.
Marsh LM, Jandl K, Grünig G, Foris V, Bashir M, Ghanim B, Klepetko W, Olschewski H, Olschewski A, Kwapiszewska G.Eur Respir J. 2018 Jan 25;51(1):1701214. doi: 10.1183/13993003.01214-2017. Print 2018 Jan.PMID: 29371380

Progressive Stenosis of Both Main Bronchi Associated With Recurrent Infections of a Carinal Pouch.
Schweiger T, Hoetzenecker K, Prosch H, Hackl M, Oszvath B, Lang G, Klepetko W.Ann Thorac Surg. 2018 Jan;105(1):e1-e3. doi: 10.1016/j.athoracsur.2017.07.037.PMID: 29233352

Lung transplantation for idiopathic pulmonary arterial hypertension on intraoperative and postoperatively prolonged extracorporeal membrane oxygenation provides optimally controlled reperfusion and excellent outcome.
Moser B, Jaksch P, Taghavi S, Muraközy G, Lang G, Hager H, Krenn C, Roth G, Faybik P, Bacher A, Aigner C, Matilla JR, Hoetzenecker K, Hacker P, Lang I, Klepetko W.Eur J Cardiothorac Surg. 2018 Jan 1;53(1):178-185. doi: 10.1093/ejcts/ezx212.PMID: 2895032

Intraoperative extracorporeal membrane oxygenation and the possibility of postoperative prolongation improve survival in bilateral lung transplantation.
Hoetzenecker K, Schwarz S, Muckenhuber M, Benazzo A, Frommlet F, Schweiger T, Bata O, Jaksch P, Ahmadi N, Muraközy G, Prosch H, Hager H, Roth G, Lang G, Taghavi S, Klepetko W.J Thorac Cardiovasc Surg. 2018 May;155(5):2193-2206.e3. doi: 10.1016/j.jtcvs.2017.10.144. Epub 2017 Dec 7.PMID: 29653665

Extracorporeal life support as a bridge to lung transplantation-experience of a high-volume transplant center.
Hoetzenecker K, Donahoe L, Yeung JC, Azad S, Fan E, Ferguson ND, Del Sorbo L, de Perrot M, Pierre A, Yasufuku K, Singer L, Waddell TK, Keshavjee S, Cypel M.J Thorac Cardiovasc Surg. 2018 Mar;155(3):1316-1328.e1. doi: 10.1016/j.jtcvs.2017.09.161. Epub 2017 Nov 22.PMID: 29248282