Welcome to the Division of Immunobiology

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Molecular Regulation of T Cell-mediated Immunity

T lymphocytes (T cells) are key cellular players in the regulation and execution of immune responses in response to foreign pathogens and also against endogenous danger such as cancer cells. Our long-term research interest is to characterize molecular mechanisms that regulate the development, differentiation and effector function of T lymphocytes. With our studies we aim to provide important and medical-relevant insight into the regulation of T cell-mediated immunity. In ongoing studies we address the following research topics:

• The role of histone deacetylases in the regulation of T cell-mediated immunity
• Transcriptional control of T cell development
• Regulation of peripheral T cell function and maintenance of T cell lineage identity and integrity

The experimental strategies to address our research interests include multi-color flow-cytometry, a variety of immunological tools, biochemical and molecular approaches, retroviral-mediated gene transduction into hematopoietic stem cells, next generation sequencing and mouse molecular genetics tools.

Research groups at the Division of Immunobiology

• Nicole Boucheron
• Wilfried Ellmeier (head of the division)
• Shinya Sakaguchi


++ 12/2020 - Narendra Dhele receives a Lady Tata International Award <link>
++ 12/2020 - Alexandra Gülich receives a L'Oreal Austria Fellowship - FOR WOMEN IN SCIENCE <link>
++ 09/2020 - Wilfried Ellmeier has been reelected as FWF board (FWF Kuratorium) member <link>
++ 07/2020 - New review published in Advances in Immunology: Histone deacetylases as targets in autoimmune and autoinflammatory diseases <link>
++ 04/2020 - New publication in Frontiers Immunology: NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4 + T Cells <link>
++ 02/2020 - New publication in JCI Insight: Histone Deacetylases 1 and 2 Restrain CD4+ Cytotoxic T Lymphocyte Differentiation <link>

++ 01/2020 - Wilfried Ellmeier starts his term as president of the Biomedical Alliance in Europe <link>
++ 12/2019 - New publication in Cell Reports: The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells <link>
++ 10/2019 - Wilfried Ellmeier is part of the organizing team that hosts the IUIS2025 congress in Vienna <link>
++ 06/2019 - Shinya Sakaguchi has been appointed as Associate Professor <link>
++ 05/2019 - New publication of the Sakaguchi laboratory: The zinc-finger transcription factor MAZR regulates iNKT cell subset differentiation <link>

Institute of Immunology (IFI)
Center for Pathophysiology, Infectiology and Immunology (CePII)

The Division of Immunobiology is part of the Institute of Immunology (IFI), which has been established in the year 1967. IFI is part of the Center for Pathophysiology, Infectiology and Immunology, Immunology (CePII), which hosts most of the research laboratories of the Medical University of Vienna working in the field of pathophysiology, allergy, infectiology and immunology.

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