Division of
Medical Biotechnology
Department of Pathophysiology and Allergy Research

Original papers 2015-2021

2021

Duan L, Celik A, Hoang JA, Schmidthaler K, So D, Yin X, Ditlof CM, Ponce M, Upton JEM, Lee JS, Hung L, Breiteneder H, Palladino C, Atkinson AR, Kim VHD, Berenjy A, Asper M, Hummel D, Wong S, Alexanian-Farr M, Magder A, Chinthrajah SR, Mukai K, Tsai M, Nadeau K, Galli SJ, Ramani AK, Szepfalusi Z, Eiwegger T:
Basophil activation test shows high accuracy in the diagnosis of peanut and tree nut allergy: The Markers of Nut Allergy Study.
Allergy 2021, (in press) [PubMed] [Full Text]

Dubiela P, Dolle-Bierke S, Aurich S, Worm M, Hoffmann-Sommergruber K:
Component-resolved diagnosis in adult patients with food-dependent anaphylaxis.
World Allergy Organ J 2021, 14, 100530. [PubMed] [Full Text]

Grilo J, Kitzmuller C, Aglas L, Sanchez Acosta G, Vollmann U, Ebner C, Horak F, Kinaciyan T, Radauer C, Ferreira F, Jahn-Schmid B, Bohle B:
IgE-cross-blocking antibodies to Fagales following sublingual immunotherapy with recombinant Bet v 1.
Allergy 2021, (in press) [PubMed] [Full Text]

Kabasser S, Hafner C, Chinthrajah S, Sindher SB, Kumar D, Kost LE, Long AJ, Nadeau KC, Breiteneder H, Bublin M:
Identification of Pru du 6 as a potential marker allergen for almond allergy.
Allergy 2021, 76, 1463-72. [PubMed] [Full Text]

Lyons SA, Datema MR, Le TM, Asero R, Barreales L, Belohlavkova S, de Blay F, Clausen M, Dubakiene R, Fernandez-Perez C, Fritsche P, Gislason D, Hoffmann-Sommergruber K, Jedrzejczak-Czechowicz M, Jongejan L, Kowalski ML, Kralimarkova TZ, Lidholm J, Papadopoulos NG, Pontoppidan B, Popov TA, Prado ND, Purohit A, Reig I, Seneviratne SL, Sinaniotis A, Vassilopoulou E, Versteeg SA, Vieths S, Zwinderman AH, Welsing PMJ, Mills ENC, Ballmer-Weber BK, Knulst AC, Fernandez-Rivas M, Van Ree R:
Walnut Allergy Across Europe: Distribution of Allergen Sensitization Patterns and Prediction of Severity.
J Allergy Clin Immunol Pract 2021, 9, 225-35. [PubMed] [Full Text]

Ruethers T, Taki AC, Karnaneedi S, Nie S, Kalic T, Dai D, Daduang S, Leeming M, Williamson NA, Breiteneder H, Mehr SS, Kamath SD, Campbell DE, Lopata AL:
Expanding the allergen repertoire of salmon and catfish.
Allergy 2021, 76, 1443-53. [PubMed] [Full Text]

Uranowska K, Kalic T, Valtsanidis V, Kitzwogerer M, Breiteneder H, Hafner C:
Expression of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma cells is downregulated upon inhibition of BRAF.
Oncol Rep 2021, (in press) [PubMed] [Full Text]

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2020

Kalic T, Kamath SD, Ruethers T, Taki AC, Nugraha R, Le TTK, Humeniuk P, Williamson NA, Hira D, Rolland JM, O'Hehir RE, Dai D, Campbell DE, Breiteneder H, Lopata AL:
Collagen-An Important Fish Allergen for Improved Diagnosis.
J Allergy Clin Immunol Pract 2020, 8, 3084-92 e10. [PubMed] [Full Text]

Klueber J, Costa J, Randow S, Codreanu-Morel F, Verhoeckx K, Bindslev-Jensen C, Ollert M, Hoffmann-Sommergruber K, Morisset M, Holzhauser T, Kuehn A:
Homologous tropomyosins from vertebrate and invertebrate: Recombinant calibrator proteins in functional biological assays for tropomyosin allergenicity assessment of novel animal foods.
Clin Exp Allergy 2020, 50, 105-16. [PubMed] [Full Text]

Tscheppe A, Palmberger D, van Rijt L, Kalic T, Mayr V, Palladino C, Kitzmuller C, Hemmer W, Hafner C, Bublin M, van Ree R, Grabherr R, Radauer C, Breiteneder H:
Development of a novel Ara h 2 hypoallergen with no IgE binding or anaphylactogenic activity.
J Allergy Clin Immunol 2020, 145, 229-38. [PubMed] [Full Text]

Villazala-Merino S, Rodriguez-Dominguez A, Stanek V, Campion NJ, Gattinger P, Hofer G, Froeschl R, Fae I, Lupinek C, Vrtala S, Breiteneder H, Keller W, Perkmann T, Nakamura R, Pickl WF, Valenta R, Eckl-Dorna J, Niederberger V:
Allergen-specific IgE levels and the ability of IgE-allergen complexes to cross-link determine the extent of CD23-mediated T-cell activation.
J Allergy Clin Immunol 2020, 145, 958-67. [PubMed] [Full Text]

Wirz OF, Üzülmez O, Jansen K, van de Veen W, Lammela A, Kainulainen L, Vuorinen T, Breiteneder H, Akdis CA, Jartti T, Akdis M:
Increased antiviral response in circulating lymphocytes from hypogammaglobulinemia patients.
Allergy 2020, 75, 3147-58. [PubMed] [Full Text]

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2019

Aina R, Dubiela P, Geiselhart S, Bublin M, Bruschi M, Radauer C, Nagl C, Humeniuk P, Asero R, Mortz CG, Hafner C, Hoffmann-Sommergruber K, Borowski T:
Distinct Lipid Transfer Proteins display different IgE-binding activities that are affected by fatty acid binding.
Allergy 2019, 74, 827-31. [PubMed] [Full Text]

Bublin M, Kostadinova M, Radauer C, Varga EM, Hafner C, Schmidthaler K, Saidova A, Maleki SJ, Szepfalusi Z, Eiwegger T, Breiteneder H:
Engineering of structural variants of the major peanut allergens Ara h 2 and Ara h 6 for allergen-specific immunotherapy.
J Allergy Clin Immunol 2019, 143, 1226-9. [PubMed] [Full Text]

Dubiela P, Del Conte R, Cantini F, Borowski T, Aina R, Radauer C, Bublin M, Hoffmann-Sommergruber K, Alessandri S:
Impact of lipid binding on the tertiary structure and allergenic potential of Jug r 3, the non-specific lipid transfer protein from walnut.
Sci Rep 2019, 9, 2007. [PubMed] [Full Text]

Humeniuk P, Geiselhart S, Battin C, Webb T, Steinberger P, Paster W, Hoffmann-Sommergruber K:
Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor.
Sci Rep 2019, 9, 7426. [PubMed] [Full Text]

Kalic T, Ellinger I, Kamath SD, Palladino C, Mayr V, Tscheppe A, Ruethers T, Waltl EE, Niederberger V, Lengger N, Radauer C, Hafner C, Lopata AL, Bublin M, Breiteneder H:
Fish-derived low molecular weight components modify bronchial epithelial barrier properties and release of pro-inflammatory cytokines.
Mol Immunol 2019, 112, 140-50. [PubMed] [Full Text]

Kalic T, Morel-Codreanu F, Radauer C, Ruethers T, Taki AC, Swoboda I, Hilger C, Hoffmann-Sommergruber K, Ollert M, Hafner C, Lopata AL, Morisset M, Breiteneder H, Kuehn A:
Patients Allergic to Fish Tolerate Ray Based on the Low Allergenicity of Its Parvalbumin.
J Allergy Clin Immunol Pract 2019, 7, 500-8. [PubMed] [Full Text]

Saidova A, Bublin M, Schmidthaler K, Fajgelj V, Klinglmueller F, Spittler A, Hafner C, Szepfalusi Z, Breiteneder H, Eiwegger T:
Evidence for a Role of TGF-beta-Activated Kinase 1 and MAP3K7 Binding Protein 3 in Peanut-Specific T-Cell Responses.
Int Arch Allergy Immunol 2019, 179, 1-7. [PubMed] [Full Text]

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2018

Datema MR, van Ree R, Asero R, Barreales L, Belohlavkova S, de Blay F, Clausen M, Dubakiene R, Fernandez-Perez C, Fritsche P, Gislason D, Hoffmann-Sommergruber K, Jedrzejczak-Czechowicz M, Jongejan L, Knulst AC, Kowalski M, Kralimarkova TZ, Le TM, Lidholm J, Papadopoulos NG, Popov TA, Del Prado N, Purohit A, Reig I, Seneviratne SL, Sinaniotis A, Versteeg SA, Vieths S, Zwinderman AH, Mills ENC, Fernandez-Rivas M, Ballmer-Weber B:
Component-resolved diagnosis and beyond: Multivariable regression models to predict severity of hazelnut allergy.
Allergy 2018, 73, 549-59. [PubMed] [Full Text]

Dubiela P, Kabasser S, Smargiasso N, Geiselhart S, Bublin M, Hafner C, Mazzucchelli G, Hoffmann-Sommergruber K:
Jug r 6 is the allergenic vicilin present in walnut responsible for IgE cross-reactivities to other tree nuts and seeds.
Sci Rep 2018, 8, 11366. [PubMed] [Full Text]

Geiselhart S, Nagl C, Dubiela P, Pedersen AC, Bublin M, Radauer C, Bindslev-Jensen C, Hoffmann-Sommergruber K, Mortz CG:
Concomitant sensitization to legumin, Fag e 2 and Fag e 5 predicts buckwheat allergy.
Clin Exp Allergy 2018, 48, 217-24. [PubMed] [Full Text]

Jordakieva G, Grabovac I, Valic E, Schmidt KE, Graff A, Schuster A, Hoffmann-Sommergruber K, Oberhuber C, Scheiner O, Goll A, Godnic-Cvar J:
Occupational exposure to ultrafine particles in police officers: no evidence for adverse respiratory effects.
J Occup Med Toxicol 2018, 13, 5. [PubMed] [Full Text]

Palladino C, Narzt MS, Bublin M, Schreiner M, Humeniuk P, Gschwandtner M, Hafner C, Hemmer W, Hoffmann-Sommergruber K, Mildner M, Palomares O, Gruber F, Breiteneder H:
Peanut lipids display potential adjuvanticity by triggering a pro-inflammatory response in human keratinocytes.
Allergy 2018, 73, 1746-9. [PubMed] [Full Text]

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2017

Anzengruber J, Bublin M, Bönisch E, Janesch B, Tscheppe A, Braun ML, Varga EM, Hafner C, Breiteneder H, Schäffer C:
Lactobacillus buchneri S-layer as carrier for an Ara h 2-derived peptide for peanut allergen-specific immunotherapy.
Mol Immunol 2017, 85, 81-8. [PubMed] [Full Text]

Dubiela P, Aina R, Polak D, Geiselhart S, Humeniuk P, Bohle B, Alessandri S, Del Conte R, Cantini F, Borowski T, Bublin M, Hoffmann-Sommergruber K:
Enhanced Pru p 3 IgE-binding activity by selective free fatty acid-interaction.
J Allergy Clin Immunol 2017, 140, 1728-31. [PubMed] [Full Text]

Ebrahimifard R, van den Driesche S, Breiteneder H, Hafner C, Vellekoop MJ:
An infrared sensor system for the analysis and differentiation of living mammalian cells using D2O based microfluidics.
Sensor Actuat B-Chem 2017, 247, 981-91. [Full Text]

Selb R, Eckl-Dorna J, Twaroch TE, Lupinek C, Teufelberger A, Hofer G, Focke-Tejkl M, Gepp B, Linhart B, Breiteneder H, Ellinger A, Keller W, Roux KH, Valenta R, Niederberger V:
Critical and direct involvement of the CD23 stalk region in IgE binding.
J Allergy Clin Immunol 2017, 139, 281-9. [PubMed] [Full Text]

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2016

Angelina A, Sirvent S, Palladino C, Vereda A, Cuesta-Herranz J, Eiwegger T, Rodriguez R, Breiteneder H, Villalba M, Palomares O:
The lipid interaction capacity of Sin a 2 and Ara h 1, major mustard and peanut allergens of the cupin superfamily, endorses allergenicity.
Allergy 2016, 71, 1284-94. [PubMed] [Full Text]

Bonyadi Rad E, Hammerlindl H, Wels C, Popper U, Ravindran Menon D, Breiteneder H, Kitzwoegerer M, Hafner C, Herlyn M, Bergler H, Schaider H:
Notch4 Signaling Induces a Mesenchymal-Epithelial-like Transition in Melanoma Cells to Suppress Malignant Behaviors.
Cancer Res 2016, 76, 1690-7. [PubMed] [Full Text]

Fioravanti V, Brandhoff L, van den Driesche S, Breiteneder H, Kitzwögerer M, Hafner C, Vellekoop MJ:
An Infrared Absorbance Sensor for the Detection of Melanoma in Skin Biopsies.
Sensors (Basel) 2016, 16, 1659. [PubMed] [Full Text]

Gepp B, Lengger N, Möbs C, Pfützner W, Radauer C, Bohle B, Breiteneder H:
Monitoring the epitope recognition profiles of IgE, IgG1, and IgG4 during birch pollen immunotherapy.
J Allergy Clin Immunol 2016, 137, 1600-3. [PubMed] [Full Text]

Lukschal A, Wallmann J, Bublin M, Hofstetter G, Mothes-Luksch N, Breiteneder H, Pali-Schöll I, Jensen-Jarolim E:
Mimotopes for Api g 5, a Relevant Cross-reactive Allergen, in the Celery-Mugwort-Birch-Spice Syndrome.
Allergy Asthma Immunol Res 2016, 8, 124-31. [PubMed] [Full Text]

Pucciarelli D, Lengger N, Takacova M, Csaderova L, Bartosova M, Breiteneder H, Pastorekova S, Hafner C:
Hypoxia increases the heterogeneity of melanoma cell populations and affects the response to vemurafenib.
Mol Med Rep 2016, 13, 3281-8. [PubMed] [Full Text]

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2015

Ackerbauer D, Bublin M, Radauer C, Varga EM, Hafner C, Ebner C, Szepfalusi Z, Fröschl R, Hoffmann-Sommergruber K, Eiwegger T, Breiteneder H:
Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy.
Int Arch Allergy Immunol 2015, 166, 13-24. [PubMed] [Full Text]

Ashjaei K, Bublin M, Smole U, Lengger N, Hafner C, Breiteneder H, Wagner S, Hoffmann-Sommergruber K:
Differential T-helper cell polarization after allergen-specific stimulation of autologous dendritic cells in polysensitized allergic patients.
Int Arch Allergy Immunol 2015, 166, 97-106. [PubMed] [Full Text]

Ashjaei K, Palmberger D, Bublin M, Bajna E, Breiteneder H, Grabherr R, Ellinger I, Hoffmann-Sommergruber K:
Atopic donor status does not influence the uptake of the major grass pollen allergen, Phl p 5, by dendritic cells.
J Immunol Methods 2015, 424, 120-30. [PubMed] [Full Text]

Blanc F, Bernard H, Ah-Leung S, Przybylski-Nicaise L, Skov PS, Purohit A, de Blay F, Ballmer-Weber B, Fritsche P, Rivas MF, Reig I, Sinaniotis A, Vassilopoulou E, Hoffmann-Sommergruber K, Vieths S, Rigby N, Mills C, Adel-Patient K:
Further studies on the biological activity of hazelnut allergens.
Clin Transl Allergy 2015, 5, 26. [PubMed] [Full Text]

Bublin M, Kostadinova M, Fuchs JE, Ackerbauer D, Moraes AH, Almeida FC, Lengger N, Hafner C, Ebner C, Radauer C, Liedl KR, Valente AP, Breiteneder H:
A Cross-Reactive Human Single-Chain Antibody for Detection of Major Fish Allergens, Parvalbumins, and Identification of a Major IgE-Binding Epitope.
PLoS One 2015, 10, e0142625. [PubMed] [Full Text]

Datema MR, Zuidmeer-Jongejan L, Asero R, Barreales L, Belohlavkova S, de Blay F, Bures P, Clausen M, Dubakiene R, Gislason D, Jedrzejczak-Czechowicz M, Kowalski ML, Knulst AC, Kralimarkova T, Le TM, Lovegrove A, Marsh J, Papadopoulos NG, Popov T, Del Prado N, Purohit A, Reese G, Reig I, Seneviratne SL, Sinaniotis A, Versteeg SA, Vieths S, Zwinderman AH, Mills C, Lidholm J, Hoffmann-Sommergruber K, Fernandez-Rivas M, Ballmer-Weber B, van Ree R:
Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey.
J Allergy Clin Immunol 2015, 136, 382-91. [PubMed] [Full Text]

Fernandez-Rivas M, Barreales L, Mackie AR, Fritsche P, Vazquez-Cortes S, Jedrzejczak-Czechowicz M, Kowalski ML, Clausen M, Gislason D, Sinaniotis A, Kompoti E, Le TM, Knulst AC, Purohit A, de Blay F, Kralimarkova T, Popov T, Asero R, Belohlavkova S, Seneviratne SL, Dubakiene R, Lidholm J, Hoffmann-Sommergruber K, Burney P, Crevel R, Brill M, Fernandez-Perez C, Vieths S, Clare Mills EN, van Ree R, Ballmer-Weber BK:
The EuroPrevall outpatient clinic study on food allergy: background and methodology.
Allergy 2015, 70, 576-84. [PubMed] [Full Text]

Guhsl EE, Hofstetter G, Lengger N, Hemmer W, Ebner C, Froschl R, Bublin M, Lupinek C, Breiteneder H, Radauer C:
IgE, IgG4 and IgA specific to Bet v 1-related food allergens do not predict oral allergy syndrome.
Allergy 2015, 70, 59-66. [PubMed] [Full Text]

Offermann LR, Bublin M, Perdue ML, Pfeifer S, Dubiela P, Borowski T, Chruszcz M, Hoffmann-Sommergruber K:
Structural and Functional Characterization of the Hazelnut Allergen Cor a 8.
J Agric Food Chem 2015, 63, 9150-8. [PubMed] [Full Text]

Pfeifer S, Bublin M, Dubiela P, Hummel K, Wortmann J, Hofer G, Keller W, Radauer C, Hoffmann-Sommergruber K:
Cor a 14, the allergenic 2S albumin from hazelnut, is highly thermostable and resistant to gastrointestinal digestion.
Mol Nutr Food Res 2015, 59, 2077-86. [PubMed] [Full Text]

Pucciarelli D, Lengger N, Takacova M, Csaderova L, Bartosova M, Breiteneder H, Pastorekova S, Hafner C:
Anti-chondroitin sulfate proteoglycan 4-specific antibodies modify the effects of vemurafenib on melanoma cells differentially in normoxia and hypoxia.
Int J Oncol 2015, 47, 81-90. [PubMed] [Full Text]

Smole U, Radauer C, Lengger N, Svoboda M, Rigby N, Bublin M, Gaier S, Hoffmann-Sommergruber K, Jensen-Jarolim E, Mechtcheriakova D, Breiteneder H:
The Major Birch Pollen Allergen Bet v 1 Induces Different Responses in Dendritic Cells of Birch Pollen Allergic and Healthy Individuals.
PLoS One 2015, 10, e0117904. [PubMed] [Full Text]

Subbarayal B, Schiller D, Möbs C, Pfützner W, Jahn-Schmid B, Gepp B, Breiteneder H, Vieths S, Bohle B:
The diversity of Bet v 1-specific IgG4 antibodies remains mostly constant during the course of birch pollen immunotherapy.
J Allergy Clin Immunol 2015, 136, 1680-2. [PubMed] [Full Text]

Xue M, Yang L, Shi DZ, Radauer C, Breiteneder H, Ma Y:
Qualitative analysis of Xinyue Capsules by high-performance liquid chromatography: Preliminary evaluation of drug quality in a Sino-Austrian joint study.
Chin J Integr Med 2015, 21, 772-7. [PubMed] [Full Text]

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