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Granitzer S, Widhalm R, Forsthuber M, Ellinger I, Desoye G, Hengstschläger M, Zeisler H, Salzer H, Gundacker C. Amino Acid Transporter LAT1 (SLC7A5) Mediates MeHg-Induced Oxidative Stress Defense in the Human Placental Cell Line HTR-8/SVneo.

The gut-associated lymphoid tissue represents an integral part of the immune system. Among the powerful players of the mucosa-associated lymphoid tissue are isolated lymphoid structures, ILSs. Additionally, in the course of cancer, ectopic lymphoid structures, ELSs, were shown to be formed at the tumor site. Both ILSs and ELSs act as multitasking information centers triggering multifaceted immune responses. An in-depth understanding of the complexity and functionality of ILSs and ELSs may lead to new directions in therapeutic interventions and/or provide help in treatment decisions as part of personalized medicine. The study recently published by researches from MSBP research group (Head: Diana Mechtcheriakova) and collaborative partners nominates ILSs as novel prognostic players orchestrating the pathobiology of metastatic colorectal cancer.

Sebastian Granitzer, Isabella Ellinger, Rumsha Khan, Katharina Gelles, Raimund Widhalm, Markus Hengstschläger, Harald Zeisler, Gernot Desoye, Lenka Tupova, Martina Ceckova, Hans Salzer, Claudia Gundacker Archives of Toxicology, 2020, https://doi.org/10.1007/s00204-020-02900-5

Vizzardelli, C., F. Zimmann, B. Nagl, C. Kitzmüller, U. Vollmann, M. Gindl, S. Tangermann, B. Jahn-Schmid, L. Kenner, and B. Bohle. NSG mice humanized with allergen-specific T cell lines as in vivo model of respiratory allergy. Allergy doi: 10.1111/all.14263 , 2020