Publications
IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes : JAKinibs suppress the interferon response in RA-FLSs. Bonelli M, Dalwigk K, Platzer A, Olmos Calvo I, Hayer S, Niederreiter B, Holinka J, Sevelda F, Pap T, Steiner G, Superti-Furga G, Smolen JS, Kiener HP, Karonitsch T. Exp Mol Med. 2019 Jul 8;51(7):75
www.ncbi.nlm.nih.gov/pubmed/31285419
MicroRNA-155 Controls T Helper Cell Activation During Viral Infection. Goncalves-Alves E, Saferding V, Schliehe C, Benson R, Kurowska-Stolarska M, Brunner JS, Puchner A, Podesser BK, Smolen JS, Redlich K, Bonelli M, Brewer J, Bergthaler A, Steiner G, Blüml S. Front Immunol. 2019 Jun 13;10:1367
www.ncbi.nlm.nih.gov/pubmed/31275315
Treg cells in autoimmunity: from identification to Treg-based therapies. Göschl L, Scheinecker C, Bonelli M. Semin Immunopathol. 2019 May;41(3):301-314.
www.ncbi.nlm.nih.gov/pubmed/30953162
CCR6 controls autoimmune but not innate immunity-driven experimental arthritis. Bonelli M, Puchner A, Göschl L, Hayer S, Niederreiter B, Steiner G, Tillmann K, Plasenzotti R, Podesser B, Georgel P, Smolen J, Scheinecker C, Blüml S. J Cell Mol Med. 2018 Aug 22.
www.ncbi.nlm.nih.gov/pubmed/30133119
Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs. Gadina M, Johnson C, Schwartz D, Bonelli M, Hasni S, Kanno Y, Changelian P, Laurence A, O'Shea JJ. J Leukoc Biol. 2018 Jul 12.
www.ncbi.nlm.nih.gov/pubmed/29999544
Non-classical monocytes as mediators of tissue destruction in arthritis. Puchner A, Saferding V, Bonelli M, Mikami Y, Hofmann M, Brunner JS, Caldera M, Goncalves-Alves E, Binder NB, Fischer A, Simader E, Steiner CW, Leiss H, Hayer S, Niederreiter B, Karonitsch T, Koenders MI, Podesser BK, O'Shea JJ, Menche J, Smolen JS, Redlich K, Blüml S. Ann Rheum Dis. 2018 Jun 29.
www.ncbi.nlm.nih.gov/pubmed/29959183
How does abatacept really work in rheumatoid arthritis? Bonelli M, Scheinecker C. Curr Opin Rheumatol. 2018 May;30(3):295-300.
www.ncbi.nlm.nih.gov/pubmed/29401118
A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis. Göschl L, Preglej T, Hamminger P, Bonelli M, Andersen L, Boucheron N, Gülich AF, Müller L, Saferding V, Mufazalov IA, Hirahara K, Seiser C, Matthias P, Penz T, Schuster M, Bock C, Waisman A, Steiner G, Ellmeier W. J Autoimmun. 2018 Jan;86:51-61
www.ncbi.nlm.nih.gov/pubmed/28964722
MicroRNA-146a governs fibroblast activation and joint pathology in arthritis. Saferding V, Puchner A, Goncalves-Alves E, Hofmann M, Bonelli M, Brunner JS, Sahin E, Niederreiter B, Hayer S, Kiener HP, Einwallner E, Nehmar R, Carapito R, Georgel P, Koenders MI, Boldin M, Schabbauer G, Kurowska-Stolarska M, Steiner G, Smolen JS, Redlich K, Blüml S. J Autoimmun. 2017 May 22.
www.ncbi.nlm.nih.gov/pubmed/28545737
Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions. Villarino A, Laurence A, Robinson GW, Bonelli M, Dema B, Afzali B, Shih HY, Sun HW, Brooks SR, Hennighausen L, Kanno Y, O'Shea JJ. Elife. 2016 Mar 21;5.
www.ncbi.nlm.nih.gov/pubmed/26999798
Abatacept (CTLA-4Ig) treatment reduces T cell apoptosis and regulatory T cell suppression in patients with rheumatoid arthritis (RA). Bonelli M, Göschl L, Blüml S, Karonitsch T, Hirahara K, Ferner E, Steiner CW, Steiner G, Smolen JS and Scheinecker C. Rheumatology (Oxford). 2016 Apr;55(4):710-20.
www.ncbi.nlm.nih.gov/pubmed/26672908
Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases. Schwartz DM, Bonelli M, Gadina M, O'Shea JJ. Nat Rev Rheumatol. 2016 Jan;12(1):25-36.
www.ncbi.nlm.nih.gov/pubmed/26633291
Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis. Blüml S, Sahin E, Saferding V, Goncalves-Alves E, Hainzl E, Niederreiter B, Hladik A, Lohmeyer T, Brunner JS, Bonelli M, Koenders MI, van den Berg WB, Superti-Furga G, Smolen JS, Schabbauer G, Redlich K. Arthritis Res Ther. 2015 Aug 26;17(1):230.
www.ncbi.nlm.nih.gov/pubmed/26307404
EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion. Yang XP, Jiang K, Hirahara K, Vahedi G, Afzali B, Sciume G, Bonelli M, Sun HW, Jankovic D, Kanno Y, Sartorelli V, O'Shea JJ, Laurence A. Sci Rep. 2015 Jun 19;5:10643.
www.ncbi.nlm.nih.gov/pubmed/26090605
Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity. Hirahara K, Onodera A, Villarino AV, Bonelli M, Sciumè G, Laurence A, Sun HW, Brooks SR, Vahedi G, Shih HY, Gutierrez-Cruz G, Iwata S, Suzuki R, Mikami Y, Okamoto Y, Nakayama T, Holland SM, Hunter CA, Kanno Y, O'Shea JJ. Immunity. 2015 May 19;42(5):877-89.
www.ncbi.nlm.nih.gov/pubmed/25992861
Strain-specific properties and T cells regulate the susceptibility to papilloma induction by Mus musculus papillomavirus 1. Handisurya A, Day PM, Thompson CD, Bonelli M, Lowy DR, Schiller JT. PLoS Pathog. 2014 Aug
www.ncbi.nlm.nih.gov/pubmed/25121947
Transcriptional and epigenetic networks of helper T and innate lymphoid cells. Shih HY, Sciumè G, Poholek AC, Vahedi G, Hirahara K, Villarino AV, Bonelli M, Bosselut R, Kanno Y, Muljo SA, O'Shea JJ. Immunol Rev. 2014 Sep;261(1):23-49.
www.ncbi.nlm.nih.gov/pubmed/25123275
Helper T Cell Plasticity: Impact of Extrinsic and Intrinsic Signals on Transcriptomes and Epigenomes. Bonelli M, Shih HY, Hirahara K, Singelton K, Laurence A, Poholek A, Hand T, Mikami Y, Vahedi G, Kanno Y, O'Shea JJ. Curr Top Microbiol Immunol. 2014 May 14
www.ncbi.nlm.nih.gov/pubmed/24831346
Autoreactive IgE is prevalent in systemic lupus erythematosus and is associated with increased disease activity and nephritis. Dema B, Pellefigues C, Hasni S, Gault N, Jiang C, Ricks TK, Bonelli M, Scheffel J, Sacré K, Jablonski M, Gobert D, Papo T, Daugas E, Illei G, Charles N, Rivera J. PLoS One. 2014 Feb
www.ncbi.nlm.nih.gov/pubmed/24587356
CD4+CD25-Foxp3+ T cells: a marker for lupus nephritis? Bonelli M, Göschl L, Blüml S, Karonitsch T, Steiner CW, Steiner G, Smolen JS, Scheinecker C. Arthritis Res Ther. 2014 Apr
www.ncbi.nlm.nih.gov/pubmed/24774748
BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis. Roychoudhuri R, Hirahara K, Mousavi K, Clever D, Klebanoff CA, Bonelli M, Sciumè G, Zare H, Vahedi G, Dema B, Yu Z, Liu H, Takahashi H, Rao M, Muranski P, Crompton JG, Punkosdy G, Bedognetti D, Wang E, Hoffmann V, Rivera J, Marincola FM, Nakamura A, Sartorelli V, Kanno Y, Gattinoni L, Muto A, Igarashi K, O'Shea JJ, Restifo NP. Nature. 2013 Jun 2.
www.ncbi.nlm.nih.gov/pubmed/23728300
Abatacept (CTLA-4Ig) treatment reduces the migratory capacity of Monocytes in patients with rheumatoid arthritis. Bonelli M, Ferner L, Savitskaya A, Steiner CW, Rath E, Smolen JS and Scheinecker C Arthritis Rheum. 2013 Mar
www.ncbi.nlm.nih.gov/pubmed/23203906
A dynamic real time in vivo and static ex vivo analysis of granulomonocytic cell migration in the collagen-induced arthritis model. Byrne R, Rath E, Hladik A, Niederreiter B, Bonelli M, Frantal S, Smolen JS, Scheinecker C. PLoS One. 2012;7(4):e35194.
www.ncbi.nlm.nih.gov/pubmed/22529989
Regulatory T cells form stable and long-lasting cell cluster with myeloid dendritic cells (DC). Herman S, Krenbek D, Klimas M, Bonelli M, Steiner CW, Pietschmann P, Smolen JS, Scheinecker C. Int Immunol. 2012 Jul;24(7):417-26.
www.ncbi.nlm.nih.gov/pubmed/22366044
Effects of 18β-Glycyrrhetinic acid in hTNFtg mice - a model of rheumatoid arthritis. Puchner A, Hayer S, Niederreiter B, Hladik A, Blueml S, Bonelli M, Scheinecker C, Smolen J, Redlich K. Wien Klin Wochenschr. 2012 Mar;124(5-6):170-6
www.ncbi.nlm.nih.gov/pubmed/22210441
HO-1 end products Biliverdin and carbon monoxide ameliorate murine collagen induced arthritis. Bonelli M, Savitskaya A, Steiner CW, Rath E, Bach F, Smolen JS, Scheinecker C Clin Exp Rheumatol. 2012 Jan-Feb;30(1):73-8.
www.ncbi.nlm.nih.gov/pubmed/22325451
Essential role for micro-RNA 155 in the pathogenesis of autoimmune arthritis. Blüml S, Bonelli M, Niederreiter B, Puchner A, Mayr G, Hayer S, Koenders MI, van den Berg WB, Smolen J, Redlich K. Arthritis Rheum. 2011 Feb 14.
www.ncbi.nlm.nih.gov/pubmed/21321928
Pathogenic aspects of systemic lupus erythematosus with an emphasis on regulatory T cells: Scheinecker C, Bonelli M, Smolen JS, J Autoimmun. 2010 Jul 15
www.ncbi.nlm.nih.gov/pubmed/20638240
Systemischer Lupus Erythematodes, Bonelli M, Scheinecker C, Wiener Klinische Wochenschrift Educational Jan. 2010
Treg and Lupus: Bonelli M, Smolen JS, Scheinecker C Ann Rheum Dis. 2010 Jan;69 Suppl 1:i65-66.
www.ncbi.nlm.nih.gov/pubmed/19995748
Phenotypic and functional analysis of CD4+CD25-Foxp3+ T cells in patients with systemic lupus erythematosus: Bonelli M, Savitskaya A, Steiner CW, Rath E, Smolen JS, Scheinecker C. J Immunol. 2009 Feb 1; 182(3):1689-95
www.ncbi.nlm.nih.gov/pubmed/19155519
Systemic lupus erythematosus patients exhibit functional deficiencies of endothelial progenitor cells: Grisar J, Steiner CW, Bonelli M, Karonitsch T, Schwarzinger I, Weigel G, Steiner G, Smolen JS. Rheumatology (Oxford). 2008 Oct; 47(10):1476-83
www.ncbi.nlm.nih.gov/pubmed/18660509
Access site management after peripheral percutaneous transluminal procedures: Neptune pad compared with conventional manual compression: Mlekusch W, Minar E, Dick P, Sabeti S, Bartok A, Haumer M, Bonelli M, Vormittag L, Koppensteiner R, Schillinger M. Radiology. 2008 Dec; 249(3):1058-63
www.ncbi.nlm.nih.gov/pubmed/18840791
Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE): Bonelli M, Savitskaya A, von Dalwigk K, Steiner CW, Aletaha D, Smolen JS, Scheinecker C. Int Immunol. 2008 Jul; 20(7):861-8
www.ncbi.nlm.nih.gov/pubmed/18469329
Foxp3 expression in CD4+ T cells of patients with systemic lupus erythematosus (SLE): A comparative phenotypic analysis: Bonelli M, Dalwigk K, Savitskaya A, Smolen JS and Scheinecker C Ann Rheum Dis. 2008 May; 67(5):664-71