Advances in the field of systems biology have increased our understanding of the mechanisms that drive autoimmunity and inflammation and led to the development of novel therapies and therapeutic
strategies, such as Janus-kinase inhibitors and precision medicine approaches. In parallel, better characterization of the complexity of clinical manifestations have increased our understanding of the sophistications of common as well as rare disease.

Future challenges will be to integrate big data derived from omics with clinical data to foster the development of stratified therapies in rheumatology and beyond.  Novel techniques such as deep learning, will help to predict disease courses and treatment responses in order to tailor treatment towards maximizing therapeutic effects and minimizing adverse events. Future studies will aim to translate molecular knowledge into clinical applications and ultimately to prevent the development of autoimmune diseases.

These and other important aspects wil be addressed in this symposium.

Josef Smolen & Michael Bonelli

Program

Speakers

• John O’Shea
  Scientific Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD, USA
• Raphaela Goldbach-Mansky
  Chief, Translational Autoinflammatory Disease Studies Unit, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA
• Daniel Solomon
  Chief, Section of Clinical Sciences, Division of Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Editor, Arthritis and Rheumatology
• Ellen Gravallese
  Chief, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; President, American College of Rheumatology; Associate Editor, New England Journal of Medicine
• Giulio Superti-Furga
  Scientific Director, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
• Kevin Winthrop
  Director, Center for Infectious Disease Studies, Oregon Health & Science University, Portland, OR, USA
• Oliver Distler
  Director, Department of Rheumatology, University Hospital Zürich, Switzerland
• Daniel Aletaha
  Head, Division of Rheumatology, Medical University of Vienna/ Vienna General Hospital; Treasurer, European League Against Rheumatism

Organized by

• Michael Bonelli
  Division of Rheumatology, Medical University of Vienna/Vienna General Hospital
• Josef Smolen
  em. Professor of Rheumatology, Medical University of Vienna; Editor, Annals of the Rheumatic Diseases