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CARAMEL

Changes in AlleRgenicity: Apple matrix and Modification Effects on LTP

Apple matrix and Modification Effects on LTP

Food allergy is a global health problem, especially in industrialized countries. Among plant food allergens, non-specific Lipid Transfer Proteins (nsLTPs) are small, basic proteins with a compact 3D structure that are highly resistant to degradation and reach the gut only slightly modified, inducing severe, potentially life-threatening, systemic reactions in allergic patients. Several efforts have been made regarding the physicochemical and immunological characteristics of nsLTPs. However, the protein structure itself does not full justify the allergen’s ability to produce a highly severe immune-response and other factors must be taken into consideration, such as the immune-modulating properties of both, food matrix interactions and post-translational modifications.

The aim of CARAMEL is to shed light on this important aspect of nsLTPs allergenicity, studying apple as a model food and using a multidisciplinary approach (medicine, molecular biology, biophysics, organic chemistry) that includes both, experimental and in silico methods. The expected findings will reveal the importance of factors that are currently undervalued regarding allergenic risk assessment. Furthermore, it will improve our concepts of allergen specific diagnosis and fine tune the management of the food allergic patients. In addition, this project contemplates many aspects of education and training for the fellow and thus provides an important step in her academic career.


Researchers of the Medical University of Vienna

The Medical University of Vienna is project coordinator under the leadership of Assoz. Prof. Karin Hoffmann-Sommergruber, Center for Pathophysiology, Infectiology and Immunology, Institute of Pathophysiology and Allergy Research.

Assoz. Prof. Karin Hoffmann-Sommergruber

Head of Projekt

Center for Pathophysiology, Infectiology and Immunology
Institute of Pathophysiology and Allergy Research

Project coworker:
Maire Curie-Stipendiatin: Dr.in Roberta Aina


Facts

TopicFP7-PEOPLE-2013: Intra-European Fellowship (IEF)
Project DurationFebruary 2015 – January 2017
Funding Volume240.733,20 €
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Projectwebsite

The aim of CARAMEL is to shed light on this important aspect of nsLTPs allergenicity, studying apple as a model food and using a multidisciplinary approach that includes both, experimental and in silico methods.
Learn more on the official procejtwebsite.

CARAMEL