Identification of early pathological processes contributing to Alzheimer's disease.
The collaborative research project DEVELAGE focuses on molecular pathways in the brain, which are shared in early development and ageing. It specifically aims to identify early pathological processes contributing to Alzheimer`s disease with the aim to improve its diagnosis and therapy.
The increasing number of elderly people will have a major impact on the prevalence of age-related diseases such as Alzheimer‘s, which threatens the sustainability of health care systems in Europe. One of the major challenges in the treatment of Alzheimer’s disease is early detection, when therapeutic measures can still slow disease progression.
However, the current knowledge is insufficient to identify the transition of normal brain ageing into Alzheimer’s disease-like brain damage. The Medical University of Vienna and the project partners have initiated the project DEVELAGE to characterise molecular pathways in the brain, which are shared in early development and ageing. The concept of DEVELAGE is based on the hypothesis that disorders of brain development contribute to age-related pathologies and that proteins and genes essential for brain development may have a role in neurodegeneration. In reverse, genes and proteins related to degeneration of the brain may contribute crucially to its development. The main approach of DEVELAGE aims at evaluating normal brain ageing and brain development to improve the understanding of what goes wrong in disease. Using advanced animal models and human tissue samples, DEVELAGE aims to identify novel factors contributing to the early pathology of neurodegenerative disorders which may be exploited in the near future as therapeutic targets.
Researchers of the Medical University
The Medical University of Vienna is the project coordinator under the leadership of Gabor G. Kovacs, MD, PhD from the Institute of Neurology.
Project coordinator: Assoc. Prof. Priv. Doz. Dr. med-Univ. Gabor G. Kovacs, MD, PhD, Institute of Neurology, MedUni Vienna
Project partners: 8
|Work programme topics adressed||HEALTH-2011- 2.2.2-2: Linking human development and ageing; Project No. HEALTH-F2-2011-278486|
|Type of funding scheme||Collaborative project Small or medium-scale focused research project|
|Project duration||01.01.2012 - 31.12.2014|
|Total Budget (EU Contribution)||2.994.137 €|
|Medical University of Vienna budget||632.040 €|