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EPISTOP

Long-term, prospective study evaluating clinical and molecular biomarkers of epileptogenesis in a genetic model of epilepsy – tuberous sclerosis complex

Long-term, prospective study evaluating clinical and molecular biomarkers of EPIleptogenesiS in a genetic model of epilepsy – Tuberous sclerOsis comPlex (EPISTOP)

Epilepsy affects 1% of the world population. About 30 – 40% are drug-resistant and 50% develop serious comorbidities. 65% of all epilepsies start during infancy and the incidence is highest in the first year of life. The earlier the onset of the disease, the greater the impact on the further development, often with severe impairment of cognition and behavior.

The underlying mechanisms of epilepsy (epileptogenesis) are still unknown, because affected people usually come after the onset of seizures under medical treatment. The previous treatment concept is therefore to prohibit further seizures (secondary prophylaxis).

Recent studies show, that a large part of epileptogenesis occurs presymptomatically, and an early treatment can possibly prevent the development of epilepsy or minimize at least its extent.

Tuberous sclerosis (TS) is an excellent clinical model to investigate epileptogenesis, because 71% of TS – patients develop epilepsy in the first year of life.

In the context of the EPISTOP-study, risk factors and biomarkers for genesis and progress of epilepsy in infants should be identified. These new targets might prevent or positively influence the course of the disease. During this project new ways and treatment-guidelines should be established and thus contributing to improving the quality of patient care and life.


MedUni Vienna Researchers

The Medical University of Vienna is project partner under the leadership of  Univ. Prof. Dr. Martha Feucht 

Univ. Prof. Dr. Martha Feucht

Department of Medicine for Child- and Youthcare
Neuro pediatric / Epilepsy–Monitoring–Unit

Research Staff

Research Staff: 
Angelika Mühlebner-Fahrngruber / Sharon Samueli / Theresa Scholl


Consortium

Project Coordinator: Prof. Sergiusz Jóźwiak / Instytut "Pomnik-Centrum Zdrowia Dziecka", Warschau, Polen.


13 project partners


Facts

TopicFP7-HEALTH.2013.2.2.1-4: 
Patho-physiology and therapy of epilepsy and epileptiform disorders / 
Collaborative Project (large-scale integrating project)
Project duration11.2013 - 10.2018
Funding volume, Medical University of Vienna535.916 €
Funding volume, total9,451.675 €

Projectwebsite

In the context of the EPISTOP-study, risk factors and biomarkers for genesis and progress of epilepsy in infants should be identified. Find out more about the Project on their official website. 

EPISTOP