Towards safe and effective immunotherapy of persistent life-threatening food allergies.
Despite the fact that food allergies can be accompanied by life-threatening systemic allergic reactions, they can, up to now, only be symptomatically treated and patients need to avoid the consumption of allergenic food. Especially for allergies to fish and fruits, as they represent persistent forms of food allergies, efficacious therapies are strongly needed. Allergen-specific immunotherapy (SIT) that is used for the treatment of allergies against inhalative allergens as well as insect venom is based on the subcutaneous application of natural allergens. However, for the therapy of food allergies SIT cannot be used due to frequently occurring severe anaphylactic side-effects. The FAST project aims at the development of safe and effective vaccines for immunotherapy of fish and fruit allergies and their investigation in clinical trials.
An IgE response to respectively one highly cross-reactive major allergen forms the basis of the two allergies, the parvalbumin Cyp c 1 regarding fish allergy and the lipid transfer protein Pru p 3 in the case of peach allergy. Through selective changes to the amino acid sequence of the proteins, hypoallergenic variants with reduced IgE reactivity and strongly decreased anaphylactic properties are produced. For the first time, these will be tested in placebo-controlled multi-centre double-blind vaccination studies (phase 2a, 2b).
MedUni Vienna Researchers
The Medical University of Vienna is project partner under the leadership of Ass.Prof. Dr. Birgit Linhart, Center for Pathophysiology, Infectiology and Immunology.
Ass.-Prof.in Univ.-Doz.in Mag.a Dr.in Ines Swoboda (ehemalige Projektleiterin)
Antonia Charis Gstöttner, Bakk. rer. nat. (Diplomandin)
Project coordinator: Prof. Dr. Ronald van Ree, Academic Medical Center of the University of Amsterdam, Niederlande.
Project partners: 16
|Topic||FP7-HEALTH / HEALTH-2007-1.4-3 / Medicine, Health / Small or medium-scale focused research project|
|Project Duration||01.09.2008 - 31.08.2015|
|Funding Volume, total||4.078.063 €|
|Funding Volume, Medical University of Vienna||340.000 €|