HYPERLAB: High yield and performance stem cell lab
The overall objectives of Hyperlab are to develop new and improved methods, media and protocols for stem cell cultivation and differentiation by developing technologies for testing of a large variety of different culture conditions for hESCs and ASCs.
On the technological side, Hyperlab aims to develop new, miniaturised microfluidics-based technologies and procedures for optimised, standardised culture and differentiation of stem cells of different sources, suitable for safe human stem cell therapy.
Three novel miniaturised cell cultivation technologies (pipe-based bioreactors, modified hanging droplets, and pipette robots) are adapted to stem cell cultivation. The most promising novel technology will be amenable to GMP standards and different clinical applications, thus ensuring a quick transfer to clinical trials.
On the cellular side, Hyperlab aims at screening stem cell culture and differentiation conditions with the novel adapted technologies, allowing to increase the number of tested variations per screening run by at least factor 100 as compared to conventional methods. Hyperlab also establishes and validates readout systems for hESCs and ASCs. This enables fast and reliable analysis of screening results and hereby determination of optimal culture and differentiation conditions.
Researchers of the Medical University of Vienna
The Medical University of Vienna is project partner under the leadership of Univ.-Doz. Dr. Andrea Kolbus / Universitätsklinik für Frauenheilkunde, Klinische Abteilung für Gynäkologische Endokrinologie und Reproduktionsmedizin.
Scientific stuff at the Medical University of Vienna:
Dr. Mario Mairhofer (senior Postdoc)
Stefanie Hofer (Diplomandin)
Martin Fröhlich (Diplomand)
Nadja Leditznig (MTA)
Ladislaus Szabo (AR; MTA)
Project coordinator: Prof. Dr. Heiko Zimmermann Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V. Fraunhofer Institut für Biomedizinische Technik (IBMT), Deutschland.
Project partners: 9
|Topic||FP7 HEALTH-2007-223011 / Small or medium-scale focused research project|
|Project duration||1.9.2009 –31.8.2012|
|Funding volume, total||2.99 Mio €|
|Funding volume, Medical Univesity of Vienna||572.572 €|