Development of a late-onset-Alzheimer's disease (LOAD) profile for accurate diagnosis and identification of potential therapeutic approaches.
Late-onset Alzheimer’s disease (LOAD) is a neurodegenerative disorder that currently affects 2% of the population in industrialized countries; the risk of LOAD increases in individuals beyond the age of 70 and it is predicted that the incidence of LOAD will increase 4-fold within the next 50 years which may cause a great socioeconomic problem. Early diagnosis and evidence-based interventions that improve the condition of LOAD patients are not available. Numerous studies revealed that LOAD is an age-related multifactorial disease, which is evident on the protein level in hardly accessible cerebrospinal fluid by decreased β amyloid and increased hyperphosphorylated tau protein.
On the genetic level LOAD is associated with Apolipoprotein E4 polymorphism. Decreased vitamin B12, folate and increased homocysteine levels are metabolic dysfunctions that may be linked to epigenetic changes in methylation patterns of LOAD relevant genes.
The University of Vienna will identify metabolic LOAD markers in blood. The Medical University of Vienna will perform complementary (epi)genetic and proteomic studies, and will generate algorithms for multi-arrays. Significant (epi)genetic aberrations in LOAD will be translated into assays of a DNA Chip at Randox. In addition, the SME Ledo and the Politechnika Lodzka join their expertise to develop a platelet isolation column kit for routine analysis. This intensive transfer of knowledge should support accurate diagnosis and approaches to targeted therapy of LOAD.
Researchers of the Medical University
The Medical University of Vienna is project coordinator under the leadership of Ass.-Prof. Dipl.-Ing. Dr. Maria Zellner / Center for physiology and pharmacology, institute for physiology.
Scientific staff at the Medical University of Vienna:
Mag. Dr. Ellen Umlauf
Project coordination: Ass.-Prof.in Dipl.-Ing.in Dr.in Maria Zellner, Center for physiology and pharmacology, institute for physiology, MedUni Vienna
Project partners: 5
|Topic||FP7-PEOPLE-2011-IAPP / Industry-Academia Partnerships and Pathways|
|Project duration||01.10.2012 - 30.09.2016|
|Funding volume, total||747.300 €|
|Funding volume, Medical University Vienna||283.608 €|