Multifaceted CaSR

The Multifaceted CaSR ITN proposed to perform basic and multidisciplinary investigations into the role of the CaSR and to provide experimental data for computational modelling of pathways activated by this receptor. Our plan is to use holistic approaches of systems biology to gain knowledge on mechanisms of CaSR function.

The main purposes of the “Multifaceted CaSR” are to:

1. Educate and train Early Stage Researchers to become excellent scientists, enable them to gain a holistic view of their specific research area, prepare them for the challenges of working in a highly competitive environment, be it in Academia or in Industry. 
2. Generate a systems biology model for CaSR-dependent signalling in order to find innovative therapeutic approaches and interventions for the natural and synthetic ligands of the CaSR.
3. Establish long lasting interdisciplinary and intersectoral cooperation among basic, clinical and applied researchers, working on the CaSR to strengthen the European Research Area

The scientific objectives of the proposed ITN will be achieved through 11 specific research projects, conducted in the Partners’ laboratories. Collectively the projects take advantage of the breadth of expertise within the Multifaceted CaSR Network, and exploit distinct contributions from Academia and Industry. Through these research projects the Multifaceted CaSR Network will train 10 ESRs and one ER in understanding the complexity of CaSR-dependent signalling in the organism as a whole.