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Multifaceted CaSR

The role of the Calcium Sensing Receptor in health and disease, implications for translational medicine

The role of the Calcium Sensing Receptor (CAsR) in health and disease, implications for translational medicine. 

The Multifaceted CaSR ITN proposed to perform basic and multidisciplinary investigations into the role of the CaSR and to provide experimental data for computational modelling of pathways activated by this receptor. Our plan is to use holistic approaches of systems biology to gain knowledge on mechanisms of CaSR function.

The main purposes of the “Multifaceted CaSR” are to:

  1. Educate and train Early Stage Researchers to become excellent scientists, enable them to gain a holistic view of their specific research area, prepare them for the challenges of working in a highly competitive environment, be it in Academia or in Industry. 
  2. Generate a systems biology model for CaSR-dependent signalling in order to find innovative therapeutic approaches and interventions for the natural and synthetic ligands of the CaSR.
  3. Establish long lasting interdisciplinary and intersectoral cooperation among basic, clinical and applied researchers, working on the CaSR to strengthen the European Research Area

The scientific objectives of the proposed ITN will be achieved through 11 specific research projects, conducted in the Partners’ laboratories. Collectively the projects take advantage of the breadth of expertise within the Multifaceted CaSR Network, and exploit distinct contributions from Academia and Industry. Through these research projects the Multifaceted CaSR Network will train 10 ESRs and one ER in understanding the complexity of CaSR-dependent signalling in the organism as a whole.

Researchers of the Medical University

The Medical University of Vienna is project coordinator under the leadership of  Assoc.Prof. Enikö Kallay, Institut für Pathophysiologie und Allergieforschung.

Assoc.Prof. Enikö Kallay

Head of Project

Institute of Pathophysiology and Allergyresearch.

Research Staff:
Ao. Univ. Prof. DI Sabina Baumgartner-Parzer, Universitätsklinik für Innere Medizin III, Klin. Abtlg. F. Endokrinologie & Stoffwechsel
MPharm Irfete Fetahu
MSc. Abhishek Aggarwal
MSc. Samawansha Tennakoon
Dott. Maria Elena Manfredini


Project coordinator: Frau Assoc.Prof. Enikö Kallay, Institut für Pathophysiologie und Allergieforschung, MedUni Vienna

Project partners:

Université de Picardie Jules Verne (F)
Cardiff University (UK)
University of Oxford (UK)
Vrije Universiteit (NL)
University of Florence (I)
AstraZeneca UK Limited (UK)

Als „assoziierte Partner“ nehmen Amgen GmbH (AUT), FH JOANNEUM GmbH (AUT) und AHT Management Kft (H) teil.


Topic7RP, People 2010, Marie Curie “Initial Training Network” (ITN)
Project duration01.01.2011 - 31.12.2014
Funding Volume, total2.915.948 €
Funding Volume, Medical University of  Vienna774.032 €


The project Multifaceted CaSR leaded by Assoc.Prof. Enikö Kallay is about Calcium Sensing Receptors (CaSR) in cardiovascular diseases and three different types of cancer.
Learn more about it on the official website.

Multifaceted CaSR