Work on this project was initiated on February 1, 2008 and was terminated on July 31, 2012. It intended to clarify the structure of Cys-loop receptors to provide a basis for a more rational development of novel drugs.
The family of Cys-loop receptors comprises the nicotinic acetylcholine receptors, the GABAA receptors, the glycine receptors and the serotonin-type3 receptors, all of which are the targets of clinically important drugs.
For all these receptors, however, receptor subtypes do exist that due to their specific location in the brain exhibit very specific functions. Malfunctioning of these receptors can lead to diseases of the nervous system that can be effectively treated by drugs selectively interacting with these receptor subtypes. In spite of the importance of these receptors for the function of the brain, no crystal structures are available for anyone of them, although such structures could enhance the development of receptor subtype-selective drugs. There are, however, crystal structures of similar proteins that could be used as templates for homology modeling of Cys-loop receptors.
This project was quite successful. Although no crystal structure of any of these receptors could be obtained, homology models of certain receptor subtypes could be derived and our knowledge on all these receptors and the drugs modulating them could be significantly increased. Furthermore, novel strategies for the development of specific drugs for these receptors could be derived.
MedUni Vienna Researchers
The MedUni Vienna is project partner under the leadership of Univ. Prof. Dr. Werner Sieghart, Center for Brain Research, Medcial University of Vienna.
Project Coordinator: Prof. Dr. August Smit, Vrije Universiteit Amsterdam, The Netherlands.
20 Project Partners
|Topic||FP7-Integrated project, HEALTH-F4-2008-202088|
|Funding volume, total||€ 11,025,000,-|
|Funding volume, Medical University of Vienna||€ 536,078,-|