Bianca S. Gerendas
MedUni Wien RESEARCHER OF THE MONTH, September 2018
The objective of the study was to identify imaging biomarkers in optical coherence tomography (OCT) predicting functional/anatomical outcomes in diabetic macular edema besides central retinal thickness (CRT). A post hoc analysis of the ranibizumab licensing studies in Europe with 345 patients has been performed. The morphological features CRT, intraretinal cystoid fluid (IRC) and subretinal fluid (SRF) have been analayzed in a multivariate model to define their impact on visual acuity (VA) after one year of treatment. A weak negative linear correlation between CRT/VA was observed before therapy (baseline, r=−0.34, p<0.001). Patients with baseline height of IRC≤380μm had significantly better baseline VA compared with patients with IRC height >380μm (p=0.0071), which was maintained after one year (p=0.0252). In conclusion, with ranibizumab treatment, the height of IRC before therapy was a better predictor of functional/anatomical improvement than CRT alone.
 Gerendas BS, Prager S, Deak G, Simader C, Lammer J, Waldstein SM, Guerin T, Kundi M, Schmidt-Erfurth UM. Predictive imaging biomarkers relevant for functional and anatomical outcomes during ranibizumab therapy of diabetic macular oedema. Br J Ophthalmol. 2018 Feb;102(2):195-203. doi: 10.1136/bjophthalmol-2017-310483. Epub 2017 Jul 19.
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