Chemokine CXCL5; Chemokines; Melanoma; Neutrophils
Events promoting tumor progression and metastasis occur at early stages of malignant cancers and usually consist of tumor – stromal, tumor - lymph/blood vessel and tumor – immune system interactions. In cutaneous melanoma, lymph node metastasis is the first hallmark of advanced stage disease, thus meaning a worse clinical prognosis with mortality rates exceeding 50%. Identification of leading signaling networks controlling lymphogenic metastasis remains a major challenge. We aim to identify tumor- and stromal-derived factors that influence metastatic behavior and to dissect their signaling and functional properties with regard to enable early lymphogenic tumor spread.
Techniques, methods & infrastructure
Metastatic mouse melanoma models, flow cytometry, qualitative and quantitative methods in protein biochemistry and molecular biology, cell and tissue culture, transfection of cells, histology and immuno-histochemistry
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- Soler-Cardona, A. and Forsthuber, A. et al., 2018. CXCL5 Facilitates Melanoma Cell-Neutrophil Interaction and Lymph Node Metastasis. Journal of Investigative Dermatology, 138(7), pp.1627-1635. Available at: http://dx.doi.org/10.1016/j.jid.2018.01.035.
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