25 hydroxyvitamin D 24 hydroxylase (CYP24A1); Nuclear receptors; Receptors, Calcium-Sensing; Signalling by G protein-coupled receptors (GPCRs); Vitamin D
- Tumour Pathology
Head: Eniko Kallay
Research Area: The goal of the Tumour Pathology Research Group is to understand and unveil cellular and molecular mechanisms that play a role in the prevention and pathogenesis of colorectal cancer and other chronic or malignant diseases. We are studying the role of vitamin D and dietary calcium in this process as well.
The molecular mechanism behind the effect of vitamin D and calcium in colorectal tumourigenesis.
- Aggarwal, A. et al., 2015. The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon. Mol Cancer, 14(1). Available at: http://dx.doi.org/10.1186/s12943-015-0330-4.
- Aggarwal, A. et al., 2015. The calcium-sensing receptor: A promising target for prevention of colorectal cancer. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1853(9), pp.2158-2167. Available at: http://dx.doi.org/10.1016/j.bbamcr.2015.02.011.
- Fetahu, I.S. et al., 2014. Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3. Int. J. Cancer, 135(9), pp.2014-2023. Available at: http://dx.doi.org/10.1002/ijc.28856.
- Hobaus, J. et al., 2013. Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer. Int. J. Cancer, 133(6), pp.1380-1388. Available at: http://dx.doi.org/10.1002/ijc.28143.
- Fetahu, I.S., HA'