Department of Otorhinolaryngology (Clinical Division of General Otorhinolaryngology)
Position: PHD Student
ORCID: 0000-0003-1881-2982
T +43 1 40400 65400
dioni.petsiou@meduniwien.ac.at
Keywords
Allergy and Immunology; Otolaryngology
Research group(s)
- Vienna Airway Lab
Head: Sven Schneider
Research Area: Type 2 inflammatory respiratory diseases, United Airway Disease, Chronic Rhinosinusitis, Respiratory Allergy
Members:
Research interests
My research focuses on investigating human IgE-associated immune responses to aeroallergens, with particular emphasis on the cellular mechanisms underlying allergic sensitization. Although IgE plays a central role in allergic disease, key aspects of its biology remain insufficiently understood, including the precise sites of IgE production and release. I am especially interested in the interactions between B cells, T cells, and tissue-specific microenvironments that drive and sustain IgE responses. By exploring these processes, my work aims to contribute to a more comprehensive understanding of allergic inflammation and to support the development of improved diagnostic and therapeutic strategies.
Techniques, methods & infrastructure
Primary human cells are employed in in vitro culture systems to model allergic immune responses under controlled conditions. A central component is the use of multiparametric flow cytometry for the phenotypic and functional characterization of allergy-related immune cell populations. In addition, immunoassays, including ELISA-based approaches, are used to quantify IgE and other relevant immune mediators.
Selected publications
- Campion, N.J. et al. (2026) ‘Dosing Interval Extension of Dupilumab in CRSwNP: Five‐Year Real World Outcomes’, International Forum of Allergy & Rhinology [Preprint]. Available at: https://doi.org/10.1002/alr.70125.
- Petsiou DP, Spinos D, Martinos A, Muzaffar J, Garas G, Georgalas C. Effectiveness of Artificial Intelligence in detecting sinonasal pathology using clinical imaging modalities: a systematic review. Rhinology. 2025 Aug 1;63(4):448-462. doi: 10.4193/Rhin25.044. PMID: 40388840.
- Petsiou DP, Martinos A, Spinos D. Applications of Artificial Intelligence in Temporal Bone Imaging: Advances and Future Challenges. Cureus. 2023 Sep 2;15(9):e44591. doi: 10.7759/cureus.44591. PMID: 37795060; PMCID: PMC10545916.
- Sideris G, Petsiou DP, Kourklidou M, Papadimitriou N, Vlastarakos PV, Karamagkiolas S, Margaris I, Nikolopoulos T, Delides A. Fungal Malignant Otitis Externa: A Systematic Review. Cureus. 2024 Oct 13;16(10):e71345. doi: 10.7759/cureus.71345. PMID: 39534824; PMCID: PMC11555462.
- Spinos D, Martinos A, Petsiou DP, Mistry N, Garas G. Artificial Intelligence in Temporal Bone Imaging: A Systematic Review. Laryngoscope. 2025 Mar;135(3):973-981. doi: 10.1002/lary.31809. Epub 2024 Oct 1. PMID: 39352072.