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Detail

Markus  Kunze
Dr.rer.nat. Markus Kunze

Center for Brain Research (Division of Pathobiology of the Nervous System)
Position: Research Assistant

T +43 1 40160 34094
markus.kunze@meduniwien.ac.at

Keywords

Adrenoleukodystrophy; Alzheimer Disease; ATP-Binding Cassette Transporters; Evolution, Molecular; Lipid Metabolism; Protein Transport

Research interests

Intracellular Transport Processes

A variety of metabolic pathways are sequestered within peroxisomes. Thus, the participating enzymes and the metabolic substrates have to be imported into this organelle. The mechanisms mediating an efficient and specific transport of soluble and membrane proteins to peroxisomes are a major focus of interest. The transfer of small organic compounds across the peroxisomal membrane by specific transporter proteins and the metabolic interconversion of these compounds within peroxisomes are the second major focus. Both aspects are of medical importance, because a dysfunction in transport processes has been linked to human diseases such as X-linked adrenoleukodystrophy, Alzheimers disease or metabolic disorders. 

Techniques, methods & infrastructure

Immunofluorescenc Microscopy, Western Blot, Subcellular Fractionation, Density Gradient Centrifugation, Yeast Two Hybrid Assay, Mammalian Two Hybrid Assay, Immunoprecipitation, Cell Culture Techniques, PCR, qRT-PCR

Selected publications

  1. Kunze M, Berger J (2014) Single Peroxisomal Enzyme and Transporter Deficiencies in Human Diseases and Mouse Models. In: , Molecular Machines Involved in Peroxisome Biogenesis and Maintenance Springer Vienna: pp 153-184
  2. Wiesinger C, Kunze M, Regelsberger G, Forss-Petter S, Berger J. (2013) Impaired Very Long-Chain Acyl-CoA β-Oxidation in Human X-ALD Fibroblasts Is a Direct Consequence of ABCD1 Transporter Dysfunction J Biol Chem, 288: 19269-19279
  3. Kunze M, Neuberger G, Maurer-Stroh S, Ma J, Eck T, Braverman N, Schmid J, Eisenhaber F, Berger J. (2011) Structural requirements for the interaction of peroxisomal targeting signal 2 and its receptor PEX7 J Biol Chem, 286(52): 45048-45062
  4. Hoftberger R*/Kunze M* (*joint authorship), Voigtlander T, Unterberger U, Regelsberger G, Bauer J, Aboul-Enein F, Garzuly F, Forss-Petter S, Bernheimer H, Berger J, Budka H (2010) Peroxisomal localization of the proopiomelanocortin-derived peptides Ss-Lipotropin and Ss-Endorphin Endocrinology, 151: 4801-4810
  5. Hoftberger R., Kunze M., Weinhofer I., Aboul-Enein F., Voigtlander T., Oezen I., Amann G., Bernheimer H., Budka H., Berger J (2007) Distribution and cellular localization of adrenoleukodystrophy protein in human tissues: Implications for X-linked adrenoleukodystrophy Neurobiol Dis, 28: 165-174