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Detail

Wolfgang Mikulits
Wolfgang MikulitsHead of Tumor Progression and Metastasis

Department of Medicine I (Institute of Cancer Research)
Position: Associate Professor

T +43 1 40160 57527
wolfgang.mikulits@meduniwien.ac.at

Further Information

Keywords

Peptide Chain Initiation, Translational; Signal Transduction

Research group(s)

  • Tumor Progression and Metastasis

Research interests

  • Mechanisms of epithelial to mesenchymal transition and liver carcinoma progression
  • Tumor-promoting cell signaling in liver cancer metastasis
  • Biomarker of liver cancer
  • Models of liver carcinoma progression
  • Selective translation control during tumor progression and metastasis

Techniques, methods & infrastructure

  • Molecular cloning
  • Cell culture of primary cells and cell lines
  • 3-dimensional culture
  • Real-time qPCR RNA immunoprecipitation
  • Flow cytometric analysis
  • ELISA; Western blot; IHC; Confocal IF
  • Xenograft mouse models
  • Invasion and metastasis assays
  • Transcriptome profiling
  • Proteomic profiling using SILAC

Grants

  • Diagnostischer und prognostischer Wert des solublen Axl im Leberkrebs (2015)
    Source of Funding: OeNB (Oesterreichische Nationalbank), Anniversary Fund
    Principal Investigator
  • Release of Soluble Axl and Gas6-Independent Axl Signaling in Hepatocellular Carcinoma (2015)
    Source of Funding: Herzfelder'sche Familienstiftung,
    Principal Investigator
  • IT-LIVER - Strategy to Inhibit TGF-beta in Liver Disease (project partner) (2012)
    Source of Funding: EU, FP7-PEOPLE-2012-ITN
    Principal Investigator
  • The Role of Axl in Hepatocellular Carcinoma Progression (2012)
    Source of Funding: FWF (Austrian Science Fund), Stand-Alone Projects
    Principal Investigator
  • Cooperation of wnt beta-catenin during Hepatocellular Carcinoma Progression (2009)
    Source of Funding: City of Vienna, Hochschuljubiläumsstiftung
    Principal Investigator
  • Functional analysis of Laminin B1 IRES in cancer progression (2008)
    Source of Funding: FWF (Austrian Science Fund), Stand-Alone Projects
    Principal Investigator
  • Jak-Stat - Signalling from Basis to Disease (project part leader) (2005)
    Source of Funding: FWF (Austrian Science Fund), Special Research Programmes (SFB 28)
    Principal Investigator

Selected publications

  1. Signaling of Axl via 14-3-3zeta Activates Autocrine Transforming Growth Factor-β Signaling in Hepatocellular Carcinoma. Hepatology, 61, 930-941.
  2. PDGF enhances IRES mediated translation of Laminin B1 by cytoplasmic accumulation of La during epithelial to mesenchymal transition. Nucleic Acids Res., 40, 9738-9749.
  3. p19ARF/p14ARF controls oncogenic functions of Stat3 in hepatocellular carcinoma. Hepatology, 54, 164-172.
  4. PDGF essentially links TGF-β signaling to nuclear β-catenin accumulation in hepatocellular carcinoma progression. Oncogene 26, 3395-3405.
  5. Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness. J. Cell Sci. 15, 1189-1202.